Tracer library / [11C]PD153035

Structure of PD153035 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 4705

[11C]PD153035

Also written as C-11 PD153035; C-11-PD153035; PD153035

Radionuclide: C-11 t½ 20.36 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 1

Glioma and brain tumours Lung cancer Prostate cancer Dosimetry and biodistribution studies

What it is

Compound class: 4-anilinoquinazoline, ATP-competitive EGFR tyrosine kinase inhibitor
Target / mechanism: Epidermal growth factor receptor (EGFR) tyrosine kinase domain PMID 35455447
Clinical application: Non-small cell lung cancer patients treated with EGFR-TKI (erlotinib), for predicting sensitivity/response and survival outcomes PMID 21903741
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX C Pro GE HealthCare	—	—	—	—	—	17624262 2007 Chin Med J (Engl) Synthesis of (11)C-PD153035 was performed in the Tracerlab FXc system.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with C-11. | Stage 30 (2026-09-18): Stage was 'investigational (evaluated in patients, pilot clinical studies)'; normalised to 'Clinical research', original wording kept here.