Tracer library / [225Ac]Ac-FAPI-46
Structure of FAPI-46 (unlabelled parent compound, from PubChem)
Unlabelled parent compoundPubChem CID 139400499

[225Ac]Ac-FAPI-46

Also written as FAPI-46
Radionuclide
Ac-225 t½ 14284.8 min
Modality
Therapy
Production route
—
Stage
Preclinical
Syntheses indexed
0
Glioma and brain tumoursFAP-directed radioligand therapy

What it is

Compound class
FAP inhibitor (FAPI)-based small molecule
Target / mechanism
Fibroblast activation protein (FAP) PMID 42242868
Clinical application
Glioblastoma PMID 42242868
Theranostic pair
[68Ga]Ga-FAPI-46

Published syntheses

No synthesis has been parsed for this agent yet.

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 1 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Diagnostic pair signal at discovery: YES - Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 42242868: 'FAP inhibitor (FAPI)–46 was radiolabeled with 68Ga for imaging and 225Ac or 177Lu for therapy'. Stage set/updated at stage 23 from PMID 42242868: 'Tumor uptake, therapeutic efficacy, immunomodulatory effects, and survival were evaluated for FAPI-46 alone or in combination with temozolomide in preclinical studies.'.
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