Tracer library / [99mTc]Tc(CO)3-ADAPT6

[99mTc]Tc(CO)3-ADAPT6

Also written as [Tc-99m]Tc(CO)3-ADAPT6

Radionuclide: Tc-99m t½ 360.6 min
Modality: SPECT
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Breast cancer Dosimetry and biodistribution studies

What it is

Compound class: ADAPT scaffold protein (albumin binding domain-derived affinity protein)
Target / mechanism: HER2 (human epidermal growth factor receptor 2) PMID 32998229
Clinical application: Breast cancer imaging (HER2 expression) using SPECT PMID 32998229
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	92.5 ± 1.5%	>99%	ADAPT6	32998229 2020 Molecules Site-specific radiolabeling of hexahistidine-containing ADAPT6 with [[99mTc]Tc(CO)3]+ to obtain a residualizing label was performed as described earlier - ADAPT6 was radiolabeled with [99mTc]Tc(CO)3 with 92.5 ± 1.5% radiochemical yield and purified to provide a radiochemical purity over 99%

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Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 32998229. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 32998229: 'ADAPT6'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to SPECT: Tc-99m is a gamma emitter used only for SPECT imaging. Linked articles: PMID 32998229. Stage set/updated at stage 39 from PMID 32998229: 'we investigated whether a co-injection of lysine or gelofusin, commonly used for reduction of renal uptake of radiolabeled peptides in clinics, would reduce the renal uptake of [99mTc]Tc(CO)3-ADAPT6 in NMRI mice.'.