Tracers / [99mTc]Tc-PSMA-I&S
[99mTc]Tc-PSMA-I&S
Also written as [99mTc]Tc-PSMA-I&S
- Radionuclide
- Tc-99m t½ 360.6 min
- Modality
- SPECT
- Production route
- —
- Stage
- —
- Syntheses indexed
- 7
What it is
- Compound class
- PSMA-targeting urea-based peptidomimetic inhibitor (2-mercaptoacetyl-D-Ser-D-Ser-D-Ser-D-Tyr-D-2-Nal-D-Lys(Sub-L-Lys-Urea-L-Glu))
- Target / mechanism
- Targets prostate-specific membrane antigen (PSMA) PMID 32382945
- Clinical application
- SPECT imaging and radioguided surgery of prostate cancer PMID 37901160
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
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- Other approvals
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- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
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Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | — | — | 32382945 2020 EJNMMI Res |
| — | — | — | — | — | — | 36645586 2023 EJNMMI Res |
| Scintomics GRP 4V Scintomics | vendor cassette | SPE | 58.7 ± 1.5% | 93.0 ± 0.3% | PSMA-I&S piCHEM, Raaba-Grambach, Austria | 36677636 2023 Molecules a Scintomics GRP 4 V module — The mean radiochemical yield was calculated based on the starting activity (2378 ± 450 MBq) and was 58.7 ± 1.5%. |
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | 75.9% yes | 96.3%, 97.6%, and 98.2% | PSMA-I&S piCHEM, Raaba-Grambach, Austria | 32358637 2020 EJNMMI Radiopharm Chem Automated labeling was performed with a Scintomics GRP 3 V module (Scintomics GmbH, Fürstenfeldbruck, Germany). — The mean yield of produced [99mTc]Tc-PSMA was 75.9% of the initial activity at start of the labeling (corrected for decay, range 74.8–77.9%) |
| Kit-based preparation | vendor cassette | — | — | >95% | PSMA-I&S | 40732291 2025 Pharmaceuticals (Basel) Radiolabeling was performed in a kit-based radiolabeling procedure. |
| Kit-based preparation | — | none | 92.05% ± 2.20% | 92.05 ± 2.20 | PSMA-I&S Tecnonuclear-Eckert Ziegler, Argentina | 37901160 2023 Front Chem The PSMA-I&S cold kit was produced and supplied by Tecnonuclear-Eckert Ziegler (Argentina). — obtaining RCY of 92.05% ± 2.20% (n = 5) |
| — | — | — | — | ≥98% | mas3-y-nal-k(Sub-KuE) | 27635024 2017 J Nucl Med a kit procedure for routine 99mTc labeling was developed |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [99mTc]Tc-PSMA-I&S.
Get in touchNotes
Added from reverse module search (stage 6); 6 article(s) with Tc-99m. Compound class inferred from precursor name (not stated outright) -- PMID 32358637: '2-mercaptoacetyl-D-Ser-D-Ser-D-Ser--D-Tyr-D-2-Nal-D-Lys (SUB-L-Lys-Urea-L-Glu)'. | Stage 28: added indication(s) oth-radioguided-surgery from consolidated missing-rubric review.