Tracer library / [188Re]Re-188-HEDP
[188Re]Re-188-HEDP
Also written as Re-188-HEDP; Re-188-Sn-HEDP
- Radionuclide
- Re-188 t½ 1020 min
- Modality
- Therapy
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 1
What it is
- Compound class
- bisphosphonate (HEDP)
- Target / mechanism
- —
- Clinical application
- Palliative treatment of painful bone metastases PMID 10941533
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Kit-based preparation | — | — | — | >95% | HEDP kit POLATOM | 29430106 2018 Indian J Nucl Med For 188Re-HEDP, 2960–3700 MBq (80–100 mCi) ReO4- in 1–2 ml was added to the cold kit and the reconstituted solution was then heated in boiling water for 25 min. |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- Therapeutic efficiency of rhenium-188-HEDP in human prostate cancer skeletal metastases.2003 · Br J Cancer · Clinical study
- [Comparison of rhenium-188, rhenium-186-HEDP and strontium-89 in palliation of painful bone metastases].2000 · Nuklearmedizin · Clinical study
- Rhenium-188-HEDP in the palliative treatment of bone metastases.2000 · Cancer Biother Radiopharm · Clinical study
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- POLATOM
- Typical final purification
- —
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Get in touchNotes
Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 6 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 29430106: 'HEDP kit'. Stage set/updated at stage 39 from PMID 24560635: 'for support of clinical studies with Rhenium-188-HEDP as an investigational medicinal product'.