Tracers / [68Ga]Ga-FAP-2286
[68Ga]Ga-FAP-2286
Also written as [68Ga]Ga-FAP-2286; [Ga-68]Ga-FAP-2286; FAP-2286; Ga-68 FAP-2286
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 7
What it is
- Compound class
- FAP-binding peptide conjugate (peptide-based FAP inhibitor radiopharmaceutical)
- Target / mechanism
- Fibroblast activation protein (FAP) PMID 34168013
- Clinical application
- PET imaging of FAP-expressing tumors, including treatment response assessment after 177Lu-FAP-2286 therapy PMID 39338305
- Theranostic pair
- <a href="/tracers/lu177-fap2286/">lu177-fap2286</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | 71.8 ± 1.9% yes | 96.2 ± 1.2% | FAP-2286 MedChemExpress | 39338305 2024 Pharmaceuticals (Basel) The synthesis was performed using a Scintomics GRP-3V module — corresponding to an average decay-corrected yield of 71.8 ± 1.9% based on the initial gallium-68 activity measured before starting the synthesis |
| Manual synthesis | — | SPE | 69 ± 4% yes | 98.9 ± 0.7% | FAP-2286 Nanchang Tanzhen Biological Technology Co., Ltd., China | 41764676 2026 EJNMMI Radiopharm Chem Radiolabeling of 68Ga with DOTA-TATE, Pentixafor and FAP-2286 was performed manually using a similar operating procedure — 69 ± 4% |
| — | — | — | — | — | — | 41432572 2026 Clin Nucl Med |
| Modular-Lab PharmTracer Eckert & Ziegler | — | — | — | — | FAP-2286 | 34168013 2022 J Nucl Med a Modular-Lab PharmTracer Modul (Eckert and Ziegler) was used |
| — | — | — | — | — | — | 42172798 2026 Bioorg Chem |
| — | — | — | — | — | DOTA-FAP-2286 | 42052981 2026 Mol Pharm |
| — | — | — | — | — | — | 41738886 2026 Clin Nucl Med |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-FAP-2286.
Get in touchNotes
Added from reverse module search (stage 6); 8 article(s) with Ga-68. Also seen with F-18[1] (too few articles for own row).