Tracers / [18F]VAT
[18F]VAT
Also written as [18F]VAT
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- benzovesamicol derivative (VAChT ligand)
- Target / mechanism
- Vesicular acetylcholine transporter (VAChT), presynaptic cholinergic biomarker PMID 37615234
- Clinical application
- —
- Theranostic pair
- <a href="/tracers/i131-vat/">i131-vat</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab FX2 N GE HealthCare | — | HPLC+SPE | — | — | tosylate precursor (-)-8 | 37615234 2023 J Labelled Comp Radiopharm The radiosynthesis was operated in a GE TRACERLab FX2N synthesis module (scheme 2) following below sequences: |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]VAT.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18.