Tracer library / [18F]PBR06

[18F]PBR06

Also written as [18F]PBR06; [F-18]PBR06; F-18 PBR06; F-18-PBR06; PBR06
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
1
Alzheimer's diseaseDementia other than Alzheimer'sEpilepsyNeuroinflammationParkinsonian syndromes and movement disordersLymphoma

What it is

Compound class
second-generation 18-kDa translocator protein (TSPO) PET radioligand
Target / mechanism
18-kDa translocator protein (TSPO), a marker of microglial/astrocytic activation PMID 42517649
Clinical application
Neuroinflammation/microglial activation imaging in multiple sclerosis patients PMID 38630948
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Synthra RNplus
Synthra
—————30875334
2019 Nucl Med Commun
F-PBR06 was synthesized using a Synthra RNplus module automatically.

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Clinical Trial-Ready Patient Cohorts for Multiple System Atrophy: Coupling Biospecimen and iPSC Banking to Longitudinal Deep-Phenotyping.
    2024 · Cerebellum · Clinical study

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18.
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