[18F]L-Glutamic

Also written as [18F]L-Glutamic; [F-18]L-Glutamic; F-18 L-Glutamic; F-18-L-Glutamic; L-Glutamic

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 0

Breast cancer Gastrointestinal and colorectal cancer Glioma and brain tumours Head and neck cancer Hepatobiliary and pancreatic cancer Lung cancer Pan-cancer / multiple tumour types Dosimetry and biodistribution studies Apoptosis and early treatment response Redox and oxidative stress

What it is

Compound class: L-glutamate analog (fluoropropyl-labeled glutamic acid derivative)
Target / mechanism: cystine/glutamate antiporter, system xc- PMID 38006500
Clinical application: Cancer detection and tumor redox/antioxidant status imaging across multiple tumor types PMID 38611114
Theranostic pair: —

Published syntheses

No synthesis has been parsed for this agent yet.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC cond.Radionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 7 article(s) with F-18. | Stage 30 (2026-09-18): Stage was 'investigational'; normalised to 'Clinical research', original wording kept here.