Tracers / [18F]L-Glutamic

[18F]L-Glutamic

Also written as [18F]L-Glutamic; [F-18]L-Glutamic; F-18 L-Glutamic; F-18-L-Glutamic; L-Glutamic
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
investigational
Syntheses indexed
0
Breast cancerGastrointestinal and colorectal cancerGlioma and brain tumoursHead and neck cancerHepatobiliary and pancreatic cancerLung cancerPan-cancer / multiple tumour typesDosimetry and biodistribution studiesApoptosis and early treatment responseRedox and oxidative stress

What it is

Compound class
L-glutamate analog (fluoropropyl-labeled glutamic acid derivative)
Target / mechanism
cystine/glutamate antiporter, system xc- PMID 38006500
Clinical application
Cancer detection and tumor redox/antioxidant status imaging across multiple tumor types PMID 38611114
Theranostic pair
—

Regulatory status

FDA
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EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

No synthesis has been parsed for this agent yet.

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC cond.Radionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 7 article(s) with F-18.