Tracers / [18F]FPEB
[18F]FPEB
Also written as [18F]FPEB; [F-18]FPEB; F-18 FPEB; F-18-FPEB; FPEB
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
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- Stage
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- Syntheses indexed
- 8
What it is
- Compound class
- 3-fluoro-5-(pyridinylethynyl)benzonitrile derivative (mGluR5 PET ligand)
- Target / mechanism
- Metabotropic glutamate receptor 5 (mGluR5) ligand PMID 32098347
- Clinical application
- PET imaging of mGluR5 in the central nervous system, including in Alzheimer's disease research PMID 32098347
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
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- Brand names
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Clinical use
- Typical injected activity
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- Uptake time
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Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | 3 yes | — | chloro-precursor (1) | 32098347 2020 Molecules a maximum 3% RCC was observed by manual synthesis at 200 ℃ from a 10 min reaction. In light of the low radiofluorination conversion, this precursor was not considered for automated radiosynthesis — a maximum 3% RCC was observed by manual synthesis at 200 ℃ from a 10 min reaction |
| TRACERlab FX2 N GE HealthCare | — | HPLC+SPE | 4 yes | — | nitro-precursor (2) ABX | 32098347 2020 Molecules For automated radiosyntheses, a GE TRACERlab™ FX2 N module with 2 and the SPI5 auxiliary SCIDY precursor (5) were performed as previously reported — upon automation and isolation, the highest RCY was only 4% (Table 2, Entry II) |
| TRACERlab FX2 N GE HealthCare | — | HPLC+SPE | 25 ± 2 yes | — | SCIDY SPI5 precursor (5) | 32098347 2020 Molecules [18F]FPEB synthesis via the SCIDY SPI5 auxiliary precursor was conducted on a GE TRACERlab™ FX2 N automated synthesis module. — resulted in a RCY of 25% ± 2%, with a molar activity (Am) of = 37 ± 13 GBq/µmol (n = 3) |
| TRACERlab FX2 N GE HealthCare | — | HPLC+SPE | 24 yes | — | SCIDY SPIAd precursor (7) | 32098347 2020 Molecules These automated reaction conditions were then applied to a novel SCIDY precursor for [18F]FPEB radiosynthesis, bearing an adamantyl-based auxiliary (SPIAd). — The SPIAd precursor (compound 7) also resulted in a 24% RCY for [18F]FPEB, and is similar to that of the SPI5 precursor (Table 2, Entry IV). |
| TRACERlab FX2 N GE HealthCare | — | HPLC+SPE | 36 ± 6 yes | — | sulfonium salt precursor (6) | 32098347 2020 Molecules we adapted the radiochemistry precursor and methodology for automated radiofluorination with the GE TRACERlab™ FX2 N synthesis module. — the sulfonium salt precursor produced [18F]FPEB with a RCY of 36% ± 6% and Am = 77 ± 35 GBq/µmol (n = 3). |
| TRACERlab FX FN GE HealthCare | custom manifold | HPLC+SPE | 2.6% | >98% | 3-nitro-5-[(pyridine-2-yl)ethynyl]benzonitrile In-house / non-commercial (various) | 25305528 2014 Appl Radiat Isot Synthesis of [18F]FPEB was carried out with a TRACERLab™ FXF-N module from GE Healthcare (Milwaukee, WI). — we have produced over 100 batches of [18F]FPEB with an average radiochemical yield of 2.6% and a highest yield of 9.2% |
| TRACERlab FX FN GE HealthCare | — | SPE | 15-25% no | ≥99% | spirocyclic iodonium(III) ylide precursor 1 | 25655630 2015 J Nucl Med GE medical systems commercial TRACERlab™ FXFN radiosynthesis module — 18F-FPEB was synthesized in 15 – 25% (n = 3) uncorrected radiochemical yields relative to 18F-fluoride |
| — | — | — | — | — | aryl-chloro precursor | 38369901 2024 J Labelled Comp Radiopharm |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FPEB.
Get in touchNotes
Added from reverse module search (stage 6); 4 article(s) with F-18.