Structure of FEDAA1106 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 9845414

[18F]FEDAA1106

Also written as [18F]FEDAA1106; [F-18]FEDAA1106

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Clinical research
Syntheses indexed: 2

Inflammatory disease Alzheimer's disease Dementia other than Alzheimer's Neuroinflammation Dosimetry and biodistribution studies

What it is

Compound class: TSPO PET radioligand
Target / mechanism: 18 kDa translocator protein (TSPO) PMID 21732107
Clinical application: Neuroinflammatory diseases (e.g. multiple sclerosis, Alzheimer's disease) PMID 21732107
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN GE HealthCare	—	—	—	—	—	22104496 2012 Appl Radiat Isot using a TRACERlab FX-FN synthesizer
—	—	HPLC+SPE	30-60% decay-corrected	—	tosyloxy-FEDAA1106	22469868 2012 Appl Radiat Isot

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. | Stage 30 (2026-09-18): Stage was 'investigational'; normalised to 'Clinical research', original wording kept here.