Tracers / [18F]FDDNP

[18F]FDDNP

Also written as [18F]FDDNP; [F-18]FDDNP; FDDNP
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
1
Pancreatic beta-cell imagingAlzheimer's diseaseAmyloid pathologyParkinsonian syndromes and movement disordersTau pathologyTraumatic brain injury / chronic traumatic encephalopathyMood and anxiety disorders (depression, bipolar disorder, anxiety, OCD)

What it is

Compound class
PET radiotracer (naphthyl-malononitrile derivative)
Target / mechanism
beta-amyloid plaques and tau neurofibrillary tangle aggregates PMID 29855843
Clinical application
Alzheimer's disease and non-AD tauopathies PMID 39762194
Theranostic pair
—

Regulatory status

FDA
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EMA (centralised)
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Other approvals
—
Brand names
—

Clinical use

Typical injected activity
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Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
———40-60%>99%2-{[6-(2,2-dicyano-1-methylvinyl)-2-naphthyl](methyl)amino}ethyl-4-methylbenzenesulfonate (DDNPTs)17051324
2007 Mol Imaging Biol

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. | Stage 28: added indication(s) neu-tbi, psy-mood from consolidated missing-rubric review.