Structure of FDDNP (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 24858429

[18F]FDDNP

Also written as [18F]FDDNP; [F-18]FDDNP; FDDNP

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Pancreatic beta-cell imaging Alzheimer's disease Amyloid pathology Parkinsonian syndromes and movement disorders Tau pathology Traumatic brain injury / chronic traumatic encephalopathy Mood and anxiety disorders (depression, bipolar disorder, anxiety, OCD)

What it is

Compound class: PET radiotracer (naphthyl-malononitrile derivative)
Target / mechanism: beta-amyloid plaques and tau neurofibrillary tangle aggregates PMID 29855843
Clinical application: Alzheimer's disease and non-AD tauopathies PMID 39762194
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	—	40-60%	>99%	2-{[6-(2,2-dicyano-1-methylvinyl)-2-naphthyl…2-{[6-(2,2-dicyano-1-methylvinyl)-2-naphthyl](methyl)amino}ethyl-4-methylbenzenesulfonate (DDNPTs)	17051324 2007 Mol Imaging Biol

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with F-18. | Stage 28: added indication(s) neu-tbi, psy-mood from consolidated missing-rubric review.