Structure of Fluorocholine (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 404592

[18F]FCH

Also written as [18F]choline; [18F]FCH; [18F]fluorocholine; [18F]Fluoromethylcholine; [F-18]choline; [F-18]FCH; [F-18]fluorocholine

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 1

Prostate cancer

What it is

Compound class: Radiolabelled choline analogue ([18F]fluoromethylcholine)
Target / mechanism: Choline kinase / choline transport (same mechanism class as 11C-choline) PMID 23579863
Clinical application: Prostate-cancer diagnosis and initial staging PMID 27694169
Theranostic pair: —

Regulatory status

FDA: No FDA (Drugs@FDA/openFDA): no [18F]fluorocholine product found (only Choline C-11, NDA203155, is FDA-approved)
EMA (centralised): No EMA medicines register export (2026-09-09): no 'fluorocholine' PET entry
Other approvals: —
Brand names: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN GE HealthCare	fixed tubing	SPE	7% not corrected	>99%	ditosylmethane ABX	23665261 2013 Appl Radiat Isot [18F]Fluoromethylcholine was prepared using an automated GE TRACERLab FXFN synthesis module. - typical non-decay corrected yields were 91 mCi (7% based upon 1.3 Ci of starting fluoride)

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

The value of baseline 18F-sodium fluoride and 18F-choline PET activity for identifying responders to radium-223 treatment in castration-resistant prostate cancer bone metastases.
2024 · Eur Radiol · Prospective
Combined bone scintigraphy and fluorocholine PET/computed tomography predicts response to radium-223 therapy in patients with prostate cancer.
2021 · Future Sci OA · Retrospective
Value of 68Ga-labeled bombesin antagonist (RM2) in the detection of primary prostate cancer comparing with [18F]fluoromethylcholine PET-CT and multiparametric MRI-a phase I/II study.
2023 · Eur Radiol · Clinical study · Phase I/II
Artificial intelligence-based versus manual assessment of prostate cancer in the prostate gland: a method comparison study.
2019 · Clin Physiol Funct Imaging · Clinical study
68Ga-PSMA-PET/CT in Patients With Biochemical Prostate Cancer Recurrence and Negative 18F-Choline-PET/CT.
2016 · Clin Nucl Med · Clinical study

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: ABX
Typical final purification: —

Need this precursor?We can point you to suppliers for [18F]FCH, or handle the enquiry for you.

Get in touch

Quality control Pharmacopoeial monograph

Ph. Eur. monograph: 2793 Fluorocholine (18F) injection
USP monograph: not verified the USP-NF monograph index is subscription-only and no public confirmation was found

AppearancepHRCP HPLCHPLC cond.Residual solvents (GC)Radionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. Cross-checked against Ph. Eur. general monograph 0125 (base set), EANM validation guideline (PMC7016057) and cGRPP guidance (PMC7881071). Draft X-marks consistent with the base set; tracer-specific analytical tests follow the specific monograph where one exists.

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

Setting up quality control?We can help you scope the equipment needed to release [18F]FCH.

Get in touch

Notes

Added from reverse module search (stage 6); 17 article(s) with F-18. Merged stage 17: +6 article(s) from f18-choline (same substance, [18F]fluoromethylcholine); combined count 23.