Tracers / [18F]FCH

[18F]FCH

Also written as [18F]choline; [18F]FCH; [18F]fluorocholine; [18F]Fluoromethylcholine; [F-18]choline; [F-18]FCH; [F-18]fluorocholine

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Prostate cancer

What it is

Compound class: Radiolabelled choline analogue ([18F]fluoromethylcholine)
Target / mechanism: Choline kinase / choline transport (same mechanism class as 11C-choline) PMID 23579863
Clinical application: Prostate-cancer diagnosis and initial staging PMID 27694169
Theranostic pair: —

Regulatory status

FDA: No FDA (Drugs@FDA/openFDA): no [18F]fluorocholine product found (only Choline C-11, NDA203155, is FDA-approved)
EMA (centralised): No EMA medicines register export (2026-09-09): no 'fluorocholine' PET entry
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	—	—	—	—	26975008 2016 Clin Nucl Med
TRACERlab FX FN GE HealthCare	fixed tubing	SPE	7% no	>99%	ditosylmethane ABX	23665261 2013 Appl Radiat Isot [18F]Fluoromethylcholine was prepared using an automated GE TRACERLab FXFN synthesis module. — typical non-decay corrected yields were 91 mCi (7% based upon 1.3 Ci of starting fluoride)

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Quality control Pharmacopoeial monograph

Ph. Eur. monograph: 2793
USP monograph: not verified — the USP-NF monograph index is subscription-only and no public confirmation was found

AppearancepHRCP HPLCHPLC cond.Residual solvents (GC)Radionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. Cross-checked against Ph. Eur. general monograph 0125 (base set), EANM validation guideline (PMC7016057) and cGRPP guidance (PMC7881071). Draft X-marks consistent with the base set; tracer-specific analytical tests follow the specific monograph where one exists.

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 17 article(s) with F-18. Merged stage 17: +6 article(s) from f18-choline (same substance, [18F]fluoromethylcholine); combined count 23.