Tracer library / [18F]FBPA

[18F]FBPA

Also written as [18F]FBPA; [F-18]FBPA; FBPA

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 6

Glioma and brain tumours Head and neck cancer Other radioligand therapy

What it is

Compound class: borono-phenylalanine derivative (amino acid analogue)
Target / mechanism: LAT1 (L-type amino acid transporter 1) PMID 42429632
Clinical application: Companion diagnostic for boron neutron capture therapy (BNCT), identifying suitable candidates PMID 42365564
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
In-house / custom built	—	—	—	—	—	27744544 2017 Ann Nucl Med Radiosynthesis of 18F-FBPA is described in the Supplementary data.
TRACERlab FX (model not stated) GE HealthCare	—	—	8.5±2.0%	98±1%	4-borono-L-phenylalanine	26159661 2015 Appl Radiat Isot a modified nucleophilic GE TRACERlab FXFDG - a RCY of 8.5±2.0%
—	—	—	15.5% ± 6.3% decay-corrected	—	spirocyclic iodonium ylide (SCIDY) precursor	42429632 2026 Mol Pharm using a spirocyclic iodonium ylide (SCIDY) precursor on a commercial module - decay-corrected radiochemical yield of 15.5% ± 6.3%
—	—	—	2.6% not corrected	—	BNBA	42365564 2026 EJNMMI Radiopharm Chem
—	—	—	0.3% not corrected	—	P-02	42365564 2026 EJNMMI Radiopharm Chem
—	—	—	3.1% not corrected	—	P-03	42365564 2026 EJNMMI Radiopharm Chem

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 26159661: 'direct electrophilic substitution of 4-borono-L-phenylalanine with [(18)F]F2 gas'. Stage set/updated at stage 39 from PMID 42429632: 'In vivo evaluation in subcutaneous xenografts showed high specificity for LAT1-positive tumors.'.