Tracer library / [18F]FAPI-74

[18F]FAPI-74

Also written as [18F]FAPI-74; [F-18]FAPI-74; F-18 FAPI-74; FAPI-74
Radionuclide
F-18 t½ 109.77 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
2
Fibroblast activation / tumour stromaPan-cancer / multiple tumour types

What it is

Compound class
Radiolabelled quinoline-based FAP-inhibitor (small molecule; Al-F-18 or cold-kit Ga-68 labelled member of the FAPI-46 family)
Target / mechanism
Fibroblast activation protein (FAP) PMID 32591493
Clinical application
Tumour-stroma imaging (FAP-family applications) PMID 32591493
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Manual synthesis—HPLC+SPE12.3 ± 6.6%
not corrected
>99%FAPI-74 precursor41779297
2026 EJNMMI Res
[18F]F-FAPI-74 radiolabeling was performed according to Naka et al. [25] with minor procedural modifications - [18F]F-FAPI-74 radiolabeling achieved an activity yield of 12.3 ± 6.6% (non-decay corrected, n = 8)
——SPE——NOTA-FAPI-7441025439
2025 J Am Heart Assoc

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Fibroblast activation protein inhibitor-PET/CT in lung cancer: a prospective single-center study with histopathological correlation of fibroblast activation protein expression.
    2026 · Int J Clin Oncol · Prospective
  2. Aged-Related Fibroblast Activation Protein Expression in Skeletal Muscles Evaluated by PET Imaging.
    2025 · J Cachexia Sarcopenia Muscle · Retrospective
  3. FDG-Avid But FAPI-Negative Intramucosal Carcinoma in a Colorectal Adenoma.
    2026 · Clin Nucl Med · Clinical study
  4. 68Ga-FAPI and 18F-FAPI PET/CT for detection of nodal metastases prior radical cystectomy in high-risk urothelial carcinoma patients.
    2025 · Eur J Nucl Med Mol Imaging · Clinical study

Precursor

Common precursor
FAPI-74 PMID 40272498 (DOI 10.1007/s00259-025-07239-6)
Suppliers seen in the literature
SOFIE (Dulles, VA, USA)
Typical final purification
SPE

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 9 article(s) with F-18.
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