Tracers / [18F]AlF-NOTA-FAPI-04
[18F]AlF-NOTA-FAPI-04
Also written as [18F]AlF-NOTA-FAPI-04; [F-18]AlF-NOTA-FAPI-04
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 7
What it is
- Compound class
- NOTA-conjugated FAP inhibitor (FAPI) small molecule, radiolabeled via Al18F chelation
- Target / mechanism
- Fibroblast activation protein (FAP) PMID 41670631
- Clinical application
- PET/CT imaging of fibroblast activation protein expression in oncologic and fibrotic diseases PMID 41670631
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | custom manifold | SPE | 26.4 ± 1.5% yes | above 99.0% | NOTA-FAPI-04 Paite Biotech, Beijing, China | 33816303 2021 Front Oncol AllinOne module (Trasis, Ans, Belgium) was used and modified — the radiochemical yield was 26.4 ± 1.5% (attenuation correction, n = 10) |
| — | — | — | — | — | — | 42109670 2026 Front Oncol |
| — | — | — | — | — | NOTA-FAPI-04 | 41670631 2026 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | — | 41515390 2025 Molecules |
| — | — | — | — | — | — | 41350473 2026 Eur J Nucl Med Mol Imaging |
| — | — | — | — | exceeded 95% | NOTA-FAPI-04 | 40365277 2025 Theranostics |
| — | — | — | — | — | — | 42234008 2026 Eur J Nucl Med Mol Imaging |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]AlF-NOTA-FAPI-04.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 33816303: 'NOTA-FAPI-04'.