Tracer library / [11C]PiB
[11C]PiB
Also written as 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole; [11C]PIB; [C-11]PIB; C-11 PIB; C-11-PIB; PIB; Pittsburgh compound B
- Radionuclide
- C-11 t½ 20.4 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Clinical research
- Syntheses indexed
- 17
What it is
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=Pittsburgh+compound+B
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| FASTlab GE HealthCare | custom manifold | SPE | — | >98% | 6-OH-BTA-0 Advanced Biochemical Compounds, ABX, Germany | 38154168 2024 Nucl Med Biol The GE FASTlab developer system was used to create the cassette design as well as the controlling tracer package. |
| FASTlab GE HealthCare | custom manifold | SPE | — | >98% | 6-OH-BTA-0 Advanced Biochemical Compounds, ABX, Germany | 38154168 2024 Nucl Med Biol The GE FASTlab developer system was used to create the cassette design as well as the controlling tracer package. |
| TRACERlab FX C Pro GE HealthCare | fixed tubing | HPLC | — | — | 6-OH-BTA-0 LIMBP, Université P. Verlaine, Metz, France | 38399432 2024 Pharmaceuticals (Basel) Synthesis was carried out on a TracerLab FX C Pro automated synthesis module. |
| TracerMaker Scansys Laboratorieteknik | fixed tubing | HPLC | — | — | 6-OH-BTA-0 ABX | 38399432 2024 Pharmaceuticals (Basel) The automated [11C]PiB radiosynthesis and product isolation was performed on a TracerMaker synthesis module (Scansys Laboratorieteknik ApS, Denmark) |
| TRACERlab FX C Pro GE HealthCare | fixed tubing | HPLC | — | — | 6-OH-BTA-0 ABX | 38399432 2024 Pharmaceuticals (Basel) The automated [11C]PiB production and product purification processes were performed on a Tracerlab FXc (GE HealthCare, Uppsala, Sweden) |
| ScanSys synthesizer Scansys Laboratorieteknik | fixed tubing | HPLC | — | — | 6-OH-BTA-0 ABX | 38399432 2024 Pharmaceuticals (Basel) The automated [11C]PiB production process was performed on either a ScanSys or TracerMaker module (Scansys Laboratorieteknik ApS, Vaerloese, Denmark) |
| TracerMaker Scansys Laboratorieteknik | fixed tubing | HPLC | — | — | 6-OH-BTA-0 ABX | 38399432 2024 Pharmaceuticals (Basel) The automated [11C]PiB production process was performed on either a ScanSys or TracerMaker module (Scansys Laboratorieteknik ApS, Vaerloese, Denmark) |
| AllinOne (AiO) Trasis | vendor cassette | HPLC+SPE | 9.8 ± 1.7% not corrected | >99% | 6-OH-BTA-0 ABX | 37788544 2023 Appl Radiat Isot using the Trasis AllinOne synthesis unit, a commonly used commercial radiochemistry module - The average non-decay-corrected yield using the Trasis method was 9.8 ± 1.7% (calculated from trapped [11C]CO2). |
| TRACERlab FX C Pro GE HealthCare | — | HPLC+SPE | 14.8 decay-corrected | 95 | 6-OH-BTA-0 Siquimia | 31659494 2019 EJNMMI Radiopharm Chem TRACERlab® FX C PRO module (GE Healthcare) - The radiochemical yield and activity (EOS) of formulated [11C] PiB from cyclotron-produced [11C]CO2 was (14.8 ± 12.1)%, decay corrected) |
| TRACERlab FX C Pro GE HealthCare | — | HPLC+SPE | 7 decay-corrected | — | 6-OH-BTA-0 Siquimia | 31659494 2019 EJNMMI Radiopharm Chem TRACERlab® FX C PRO module (GE Healthcare) - an average activity of [11C] PiB (EOS) of about 3.14 GBq (RCY 7%, dc) |
| TracerMaker Scansys Laboratorieteknik | — | — | — | — | — | 42140884 2026 J Labelled Comp Radiopharm a fully automated TracerMaker radiosynthesizer for routine production of multiple 11C-labeled PET tracers |
| CFN-MPS100 Sumitomo | — | SPE | 40±5% decay-corrected | >97% | — | 38454773 2024 Curr Radiopharm fully automated radiosynthesis of [11C]PiB in a commercially available synthesizer, MPS-100 (SHI, Japan) - decay-corrected radiochemical yield of 40±5% |
| In-house / custom built Laboratory | — | SPE | 22% not corrected | — | — | 28981146 2017 J Labelled Comp Radiopharm we report a novel, highly efficient solid phase supported carbon-11 radiolabeling procedure using commercially available disposable tC18 cartridge as a "3-in-1" entity: reactor, purifier, and solvent replacement system - in 22% isolated yield not corrected for decay |
| — | — | HPLC | — | >98% | — | 26248085 2015 Appl Radiat Isot |
| TRACERlab FX C Pro GE HealthCare | — | — | 32.9 ± 6.6 decay-corrected | >99% | 6-OH-BTA-0 | 21897309 2011 Nucl Med Commun [\u00b9\u00b9C]methyl iodide and [\u00b9\u00b9C]methyl triflate were produced in the TRACERlab FXC Pro synthesis box. Methylation reactions and the final formulation were performed using the AutoLoop (captive solvent method) and the ReFORM-plus systems, respectively. - Good radiochemical yields (51.3 \u00b1 11.2 and 32.9 \u00b1 6.6%, referred to as [\u00b9\u00b9C]methyl iodide, decay corrected) |
| — | — | — | 48.0±2.7% decay-corrected | >99% | — | 21550258 2011 Appl Radiat Isot |
| — | — | HPLC | 13+/-15% | >99% | 2-(4'-aminophenyl)-6-hydroxybenzothiazole | 18769311 2008 Nucl Med Commun we reported the first fully automated synthesis of [11C]PIB with the coupling of two commercial synthesizers - resulting in a total radiochemical yield of 13+/-15% after a synthesis time of 25 min |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- Association of In Vivo [18F]AV-1451 Tau PET Imaging Results With Cortical Atrophy and Symptoms in Typical and Atypical Alzheimer Disease.2017 · JAMA Neurol · Clinical study
- Visual Versus Fully Automated Analyses of 18F-FDG and Amyloid PET for Prediction of Dementia Due to Alzheimer Disease in Mild Cognitive Impairment.2016 · J Nucl Med · Clinical study
- Reproducibility of automated simplified voxel-based analysis of PET amyloid ligand [11C]PIB uptake using 30-min scanning data.2009 · Eur J Nucl Med Mol Imaging · Clinical study
- Voxel-based analysis of 11C-PIB scans for diagnosing Alzheimer's disease.2008 · J Nucl Med · Clinical study
Precursor
- Common precursor
- 6-OH-BTA-0 (desmethyl-PiB) PMID 38399432 / DOI 10.3390/ph17020217
- Suppliers seen in the literature
- 6-OH-BTA-0 (desmethyl) precursor from ABX advanced biochemical compounds (Radeberg, Germany) or Pharmasynth AS (Tartu, Estonia)
- Cited suppliers in indexed syntheses
- ABX, Advanced Biochemical Compounds, LIMBP, Université P. Verlaine, Siquimia
- Typical final purification
- —
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Get in touchQuality control Derived from the published synthesis
- Ph. Eur. monograph
- no monograph none (general monograph 0125 applies)
- USP monograph
- not verified the USP-NF monograph index is subscription-only and no public confirmation was found
How this set was arrived at. Cross-checked against Ph. Eur. general monograph 0125 (base set), EANM validation guideline (PMC7016057) and cGRPP guidance (PMC7881071). Draft X-marks consistent with the base set; tracer-specific analytical tests follow the specific monograph where one exists.
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]PiB.
Get in touchNotes
Short half-life restricts use to sites with an on-site cyclotron.