Tracers / [11C]PiB
[11C]PiB
Also written as 2-(4-N-[11C]methylaminophenyl)-6-hydroxybenzothiazole; [11C]PIB; [C-11]PIB; C-11 PIB; C-11-PIB; PIB; Pittsburgh compound B
- Radionuclide
- C-11 t½ 20.4 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Clinical research
- Syntheses indexed
- 25
What it is
- Compound class
- Benzothiazole
- Target / mechanism
- Fibrillar amyloid-beta plaques PMID 23757761 / DOI 10.1093/brain/awt142
- Clinical application
- Alzheimer's disease research; amyloid quantification PMID 23757761 / DOI 10.1093/brain/awt142
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=Pittsburgh+compound+B
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| FASTlab GE HealthCare | custom manifold | SPE | — | >98% | 6-OH-BTA-0 Advanced Biochemical Compounds, ABX, Germany | 38154168 2024 Nucl Med Biol The GE FASTlab developer system was used to create the cassette design as well as the controlling tracer package. |
| FASTlab GE HealthCare | custom manifold | SPE | — | >98% | 6-OH-BTA-0 Advanced Biochemical Compounds, ABX, Germany | 38154168 2024 Nucl Med Biol The GE FASTlab developer system was used to create the cassette design as well as the controlling tracer package. |
| TRACERlab FX C Pro GE HealthCare | fixed tubing | HPLC | — | — | 6-OH-BTA-0 LIMBP, Université P. Verlaine, Metz, France | 38399432 2024 Pharmaceuticals (Basel) Synthesis was carried out on a TracerLab FX C Pro automated synthesis module. |
| TracerMaker Scansys Laboratorieteknik | fixed tubing | HPLC | — | — | 6-OH-BTA-0 ABX | 38399432 2024 Pharmaceuticals (Basel) The automated [11C]PiB radiosynthesis and product isolation was performed on a TracerMaker synthesis module (Scansys Laboratorieteknik ApS, Denmark) |
| TRACERlab FX C Pro GE HealthCare | fixed tubing | HPLC | — | — | 6-OH-BTA-0 ABX | 38399432 2024 Pharmaceuticals (Basel) The automated [11C]PiB production and product purification processes were performed on a Tracerlab FXc (GE HealthCare, Uppsala, Sweden) |
| ScanSys synthesizer Scansys Laboratorieteknik | fixed tubing | HPLC | — | — | 6-OH-BTA-0 ABX | 38399432 2024 Pharmaceuticals (Basel) The automated [11C]PiB production process was performed on either a ScanSys or TracerMaker module (Scansys Laboratorieteknik ApS, Vaerloese, Denmark) |
| TracerMaker Scansys Laboratorieteknik | fixed tubing | HPLC | — | — | 6-OH-BTA-0 ABX | 38399432 2024 Pharmaceuticals (Basel) The automated [11C]PiB production process was performed on either a ScanSys or TracerMaker module (Scansys Laboratorieteknik ApS, Vaerloese, Denmark) |
| AllinOne (AiO) Trasis | vendor cassette | HPLC+SPE | 9.8 ± 1.7% no | >99% | 6-OH-BTA-0 ABX | 37788544 2023 Appl Radiat Isot using the Trasis AllinOne synthesis unit, a commonly used commercial radiochemistry module — The average non-decay-corrected yield using the Trasis method was 9.8 ± 1.7% (calculated from trapped [11C]CO2). |
| TRACERlab FX C Pro GE HealthCare | — | HPLC+SPE | 14.8 yes | 95 | 6-OH-BTA-0 Siquimia | 31659494 2019 EJNMMI Radiopharm Chem TRACERlab® FX C PRO module (GE Healthcare) — The radiochemical yield and activity (EOS) of formulated [11C] PiB from cyclotron-produced [11C]CO2 was (14.8 ± 12.1)%, decay corrected) |
| TRACERlab FX C Pro GE HealthCare | — | HPLC+SPE | 7 yes | — | 6-OH-BTA-0 Siquimia | 31659494 2019 EJNMMI Radiopharm Chem TRACERlab® FX C PRO module (GE Healthcare) — an average activity of [11C] PiB (EOS) of about 3.14 GBq (RCY 7%, dc) |
| — | — | — | — | — | — | 25319699 2014 J Neurosci |
| — | — | HPLC+SPE | 14.5% | — | 2-(4-aminophenyl)-6-hydroxybenzothiazole | 18632806 2008 J Nucl Med |
| — | — | — | — | — | — | 26461913 2015 PLoS One |
| In-house / custom built | custom manifold | — | — | >95% | — | 34912209 2021 Front Aging Neurosci manufactured at the Cyclotron and Radioisotope Center of Tohoku University using a semiautomated system developed in-house |
| — | — | — | — | — | — | 42140884 2026 J Labelled Comp Radiopharm a fully automated TracerMaker radiosynthesizer for routine production of multiple 11C-labeled PET tracers |
| — | — | SPE | 40±5% yes | more than 97% | — | 38454773 2024 Curr Radiopharm fully automated radiosynthesis of [11C]PiB in a commercially available synthesizer, MPS-100 (SHI, Japan) — decay-corrected radiochemical yield of 40±5% |
| — | — | SPE | — | — | — | 31710043 2019 J Vis Exp |
| — | — | SPE | 22% no | — | — | 28981146 2017 J Labelled Comp Radiopharm we report a novel, highly efficient solid phase supported carbon-11 radiolabeling procedure using commercially available disposable tC18 cartridge as a "3-in-1" entity: reactor, purifier, and solvent replacement system — in 22% isolated yield not corrected for decay |
| — | — | HPLC | — | above 98% | — | 26248085 2015 Appl Radiat Isot |
| — | — | — | 32.9 ± 6.6 yes | >99% | 6-OH-BTA-0 | 21897309 2011 Nucl Med Commun [\u00b9\u00b9C]methyl iodide and [\u00b9\u00b9C]methyl triflate were produced in the TRACERlab FXC Pro synthesis box. Methylation reactions and the final formulation were performed using the AutoLoop (captive solvent method) and the ReFORM-plus systems, respectively. — Good radiochemical yields (51.3 \u00b1 11.2 and 32.9 \u00b1 6.6%, referred to as [\u00b9\u00b9C]methyl iodide, decay corrected) |
| — | — | — | 48.0±2.7% yes | >99% | — | 21550258 2011 Appl Radiat Isot |
| — | — | HPLC | 13+/-15% | more than 99% | 2-(4'-aminophenyl)-6-hydroxybenzothiazole | 18769311 2008 Nucl Med Commun we reported the first fully automated synthesis of [11C]PIB with the coupling of two commercial synthesizers — resulting in a total radiochemical yield of 13+/-15% after a synthesis time of 25 min |
| — | — | — | — | — | — | 26585056 2016 J Nucl Med |
| — | — | — | — | — | — | 19495749 2009 Eur J Nucl Med Mol Imaging |
| — | — | — | — | — | — | 42142951 2026 J Nucl Cardiol |
Precursor
- Common precursor
- 6-OH-BTA-0 (desmethyl-PiB) PMID 38399432 / DOI 10.3390/ph17020217
- Suppliers seen in the literature
- 6-OH-BTA-0 (desmethyl) precursor from ABX advanced biochemical compounds (Radeberg, Germany) or Pharmasynth AS (Tartu, Estonia)
- Cited suppliers in indexed syntheses
- ABX, Advanced Biochemical Compounds, LIMBP, Université P. Verlaine, Siquimia
- Typical final purification
- —
Need this precursor?We can point you to suppliers for [11C]PiB, or handle the enquiry for you.
Get in touchQuality control Derived from the published synthesis
- Ph. Eur. monograph
- no specific monograph
- USP monograph
- not verified — the USP-NF monograph index is subscription-only and no public confirmation was found
How this set was arrived at. Cross-checked against Ph. Eur. general monograph 0125 (base set), EANM validation guideline (PMC7016057) and cGRPP guidance (PMC7881071). Draft X-marks consistent with the base set; tracer-specific analytical tests follow the specific monograph where one exists.
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [11C]PiB.
Get in touchNotes
Short half-life restricts use to sites with an on-site cyclotron.