Tracer library / [11C]-(+)-alpha-DTBZ
[11C]-(+)-alpha-DTBZ
Also written as [11C]-(+)-alpha-DTBZ
- Radionuclide
- C-11
- Modality
- —
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- Dihydrotetrabenazine derivative (VMAT2 ligand)
- Target / mechanism
- Vesicular monoamine transporter 2 (VMAT2) PMID 18208777
- Clinical application
- Imaging of dopaminergic nerve terminal loss in Parkinson's disease; marker of dopaminergic terminal densities in human striatum and beta cells in pancreas PMID 18208777
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — PET Co., Ltd. (Beijing) | custom manifold | SPE | 82.3 ± 3.6% decay-corrected | >99% | (+)-desmethyldihydrotetrabenazine ABX | 22728363 2012 Molecules a Methiodine Module and Methylation Module (PET Beijing Science and Technology Co., Ltd., Beijing, China) were remotely controlled by a standard PC — Radiochemical yields based on [11C]-methyl triflate (corrected for decay) were 82.3% ± 3.6% |
| — | — | SPE | — | >99% | (+)desmethyldihydrotetrabenazine | 18208777 2008 Rev Esp Med Nucl |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
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Added at stage 39 (2026-09-27) from a reverse search of the PubMed corpus's own unattached articles (articles that named a real compound not yet in this reference): 2 article(s) found under this name, not yet individually researched. Target/mechanism, clinical application, indications, approval, modality, stage and production route are intentionally left empty. PMIDs: 18208777, 22728363.