Tracer library / [225Ac]Ac-DOTAZOL

[225Ac]Ac-DOTAZOL

Also written as [Ac-225]Ac-DOTAZOL; DOTAZOL

Radionuclide: Ac-225 t½ 14284.8 min
Modality: Therapy
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Bone metastases and bone lesions Other radioligand therapy

What it is

Compound class: DOTA-conjugated bisphosphonate (zoledronic acid derivative)
Target / mechanism: Bone mineral (hydroxyapatite) targeting via bisphosphonate moiety PMID 29564390
Clinical application: Bone metastases (palliative alpha-therapy for painful skeletal metastases) PMID 29866026
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis n/a	—	none	≥98 %	—	DOTAZOL	29866026 2018 Curr Radiopharm DOTAZOL was labelled with 225Ac and injected without further purification into the tail vein - Radiolabelling of DOTAZOL with 225Ac at 98 °C provided radiochemical yields ≥98 % within 30 minutes.

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty.