Tracer library / [99mTc]Tc-TcO2

[99mTc]Tc-TcO2

Also written as [99mTc]TcO2; [Tc-99m]TcO2

Radionuclide: Tc-99m t½ 360.6 min
Modality: SPECT
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Prostate cancer

What it is

Compound class: PSMA-binding small-molecule radioligand
Target / mechanism: PSMA (prostate-specific membrane antigen) PMID 40135799
Clinical application: Prostate cancer imaging PMID 40135799
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	none	—	89.8% to 97.4%	2	40135799 2025 J Med Chem Similarly, the RCP of the product was determined by radio-HPLC (methods A and B) and the absence of 99mTc/99Tc-colloid formation was confirmed by radio-TLC.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMetal impurities

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Tc-99m. Compound class inferred from precursor name (not stated outright) -- PMID 40135799: 'the two derivatives 2 and 3'. Stage set/updated at stage 39 from PMID 40135799: 'Six 99mTc-labeled PSMA radioligands were synthesized and biologically characterized in cell-based assays and by SPECT imaging in LNCaP tumor-bearing mice.'.