Tracer library / [99mTc]Tc-N4-PSMA-12

[99mTc]Tc-N4-PSMA-12

Also written as [99mTc]Tc-N4-PSMA-12; [Tc-99m]Tc-N4-PSMA-12

Radionuclide: Tc-99m t½ 360.6 min
Modality: SPECT
Production route: —
Stage: Preclinical
Syntheses indexed: 1

Prostate cancer Radioguided / image-guided surgery (intraoperative)

What it is

Compound class: N4-PSMA ligand (PSMA-targeted small-molecule inhibitor)
Target / mechanism: Prostate-specific membrane antigen (PSMA) inhibitor PMID 36645586
Clinical application: Radioguided surgery (RGS) for recurrent prostate cancer PMID 36645586
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	—	SPE	—	98.5 ± 0.6%	N4-PSMA-12 peptide precursor	36645586 2023 EJNMMI Res

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impurities

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Tc-99m. Compound class inferred from precursor name (not stated outright) -- PMID 36645586: 'N4-PSMA-12 peptide precursor'. Stage set/updated at stage 23 from PMID 36645586: 'Three 99mTc-labeled N4-PSMA ligands were preclinically evaluated and compared to [99mTc]Tc-PSMA-I&S.'. | Stage 28: added indication(s) oth-radioguided-surgery from consolidated missing-rubric review.