Tracer library / [99mTc]Tc-N4-Bombesin

[99mTc]Tc-N4-Bombesin

Also written as [99mTc]Tc-N4-Bombesin; [Tc-99m]Tc-N4-Bombesin

Radionuclide: Tc-99m t½ 360.6 min
Modality: SPECT
Production route: —
Stage: Preclinical
Syntheses indexed: 0

Prostate cancer Receptor expression phenotyping

What it is

Compound class: N4-bombesin peptide derivative (radiolabeled GRPR-targeting peptide)
Target / mechanism: Gastrin-releasing peptide receptor (GRPR) PMID 36145354
Clinical application: Tumor imaging in GRPR-expressing tumors, evaluated in PC-3 prostate cancer xenograft model PMID 36145354
Theranostic pair: —

Published syntheses

No synthesis has been parsed for this agent yet.

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impurities

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Tc-99m. Stage set/updated at stage 39 from PMID 36145354: 'biodistribution and μSPECT/CT studies at 1 h post injection (p.i.) in PC-3 tumor-bearing CB17-SCID mice'.