Tracers / [161Tb]Tb-crown

[161Tb]Tb-crown

Also written as [Tb-161]Tb-crown

Radionuclide: Tb-161 t½ 9907.2 min
Modality: Therapy
Production route: —
Stage: —
Syntheses indexed: 4

Dosimetry and biodistribution studies

What it is

Compound class: crown-αMSH (macrocyclic crown chelator conjugated to alpha-melanocyte-stimulating hormone peptide)
Target / mechanism: —
Clinical application: —
Theranostic pair: —

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
miniAllinOne Trasis	custom manifold	SPE	— yes	99.9939	crown-αMSH	36459299 2022 EJNMMI Radiopharm Chem The process outlined in Fig. 3d was automated using a TRASIS Mini AiO module (Fig. 4).
Manual synthesis	—	SPE	90	—	crown-αMSH	36459299 2022 EJNMMI Radiopharm Chem We also tried performing purification entirely manually, and the results show better overall removal of Gd (2.3 ng for 75 MBq 161Tb). — 190 MBq of unpurified 161Tb was successfully purified with an activity recovery 90% (1.08 MBq/µL at EOS).
—	custom manifold	HPLC	— yes	99.9947	crown-αMSH	36459299 2022 EJNMMI Radiopharm Chem One portion was purified using the HPIC method (Cassells et al. 2021) at the Belgian Nuclear Research Center (SCK CEN).
Manual synthesis	—	—	85.5 ± 5.0%	—	crown-4Py	35704752 2022 Inorg Chem A 10 μL aliquot of the respective chelator, or deionized water as a negative control, was further diluted with 80 μL of deionized water and for 203Pb labeling studies, [203Pb]Pb(OAc)2 (85 kBq, 10 μL, 1 M NH4OAc, pH 7) was added and mixed at ambient temperature to begin the reaction. — The RCYs for crown-4Py at concentrations between 10−4 and 10−7 M were 85.5 ± 5.0%, 45.3 ± 1.4%, 2.0 ± 3.5%, and 0%, respectively.

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 36459299: 'biodistribution of [161Tb]Tb-crown-αMSH'.