Tracer library / [188Re]Re-188-HDD/lipiodol
[188Re]Re-188-HDD/lipiodol
Also written as Re-188-HDD/lipiodol; Re-188-HDD/Lipiodol
- Radionuclide
- Re-188 t½ 1020 min
- Modality
- Therapy
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 3
What it is
- Compound class
- HDD/Lipiodol (rhenium-188 labeled lipiodol via HDD chelator)
- Target / mechanism
- —
- Clinical application
- Hepatocellular carcinoma (liver cancer) treated by intra-arterial administration PMID 16333675
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | — | >95% | HDD/lipiodol kit ABX | 29430106 2018 Indian J Nucl Med For 188Re-HDD/Lipiodol, 3700–4440 MBq (100–120 mCi) ReO4- in 1–2 ml was added to the HDD kit and vortexed for 5 min. |
| Comecer Taddeo Comecer | — | — | 52.68±9.6% | 92.52±2.3% | Lipiodol | 21106381 2011 Appl Radiat Isot The synthesis has been automated with a TADDEO module (Comecer) - giving a mean final yield of 52.68±9.6% |
| — | — | — | — | >97% | Lipiodol | 8935963 1996 Appl Radiat Isot |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- (188)Re-HDD/lipiodol therapy for hepatocellular carcinoma: an activity escalation study.2006 · Eur J Nucl Med Mol Imaging · Clinical study
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
Need this precursor?We can point you to suppliers for [188Re]Re-188-HDD/lipiodol, or handle the enquiry for you.
Get in touchNotes
Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 4 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 29430106: 'The precursors used in the synthesis of 188Re-labeled HDD/Lipiodol were obtained from ABX GmbH, Germany'. Stage set/updated at stage 39 from PMID 19521309: 'Clinical data derived from several phase I and II studies using 188Re-HDD/Lipiodol suggest an excellent tolerance in patients with Child-Pugh A cirrhosis.'.