Tracers / [212Pb]Pb-PSMA-617
[212Pb]Pb-PSMA-617
Also written as PSMA-617; Pluvicto; [Pb-212]Pb-PSMA-617
- Radionuclide
- Pb-212 t½ 638.4 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- PSMA-617, a PSMA-targeted urea-based small-molecule radioligand
- Target / mechanism
- PSMA (prostate-specific membrane antigen) PMID 42159963
- Clinical application
- Treatment of advanced prostate cancer PMID 42159963
- Theranostic pair
- <a href="/tracers/in111-psma617/">in111-psma617</a>
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | SPE | 46.3 ± 1.7% | >98% | PSMA-617 Novartis | 42159963 2026 EJNMMI Radiopharm Chem In a 1.5 mL protein Eppendorf tube (LoBind®), approximately 37.0 MBq of 177LuCl3 in 0.25 M NaOAc buffer (pH 5.5, 100 µL) or 18.5 MBq of 212PbCl2 in 0.2 M NaOAc buffer (pH 5.5, 100 µL) was mixed with PSMA-617 (1.0 nmol, 1.0 µL). — Sep-Pak purification of the crude mixture after radiolabeling yielded [212Pb]Pb-PSMA-617 in 46.3 ± 1.7% (n = 4) yield |
| — | — | — | — | — | PSMA-617 | 31919866 2020 J Labelled Comp Radiopharm Both ligands were efficiently labelled with 212 Pb using a 224 Ra/212 Pb-solution generator in transient equilibrium with progeny. |
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Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Diagnostic pair signal at discovery: YES - Ga-68, In-111. Compound class inferred from precursor name (not stated outright) -- PMID 42159963: 'PSMA-617'.