Tracer library / [212Pb]Pb-PSMA-617

Structure of PSMA-617 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 122706786

[212Pb]Pb-PSMA-617

Also written as PSMA-617; Pluvicto; [Pb-212]Pb-PSMA-617

Radionuclide: Pb-212 t½ 638.4 min
Modality: Therapy
Production route: —
Stage: —
Syntheses indexed: 2

Prostate cancer

What it is

Compound class: PSMA-617, a PSMA-targeted urea-based small-molecule radioligand
Target / mechanism: PSMA (prostate-specific membrane antigen) PMID 42159963
Clinical application: Treatment of advanced prostate cancer PMID 42159963
Theranostic pair: [111In]In-PSMA-617

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	SPE	46.3 ± 1.7%	>98%	PSMA-617 Novartis	42159963 2026 EJNMMI Radiopharm Chem In a 1.5 mL protein Eppendorf tube (LoBind®), approximately 37.0 MBq of 177LuCl3 in 0.25 M NaOAc buffer (pH 5.5, 100 µL) or 18.5 MBq of 212PbCl2 in 0.2 M NaOAc buffer (pH 5.5, 100 µL) was mixed with PSMA-617 (1.0 nmol, 1.0 µL). - Sep-Pak purification of the crude mixture after radiolabeling yielded [212Pb]Pb-PSMA-617 in 46.3 ± 1.7% (n = 4) yield
Manual synthesis n/a	—	—	—	—	PSMA-617	31919866 2020 J Labelled Comp Radiopharm Both ligands were efficiently labelled with 212 Pb using a 224 Ra/212 Pb-solution generator in transient equilibrium with progeny.

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Novartis
Typical final purification: —

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Diagnostic pair signal at discovery: YES - Ga-68, In-111. Compound class inferred from precursor name (not stated outright) -- PMID 42159963: 'PSMA-617'.