Tracers / [177Lu]Lu-PSMA-10

[177Lu]Lu-PSMA-10

Also written as [177Lu]Lu-PSMA-10; [Lu-177]Lu-PSMA-10

Radionuclide: Lu-177 t½ 9585 min
Modality: Therapy
Production route: —
Stage: —
Syntheses indexed: 1

What it is

Compound class: Urea-based PSMA-targeted DOTA-conjugated peptide inhibitor (Glu-urea-Glu)
Target / mechanism: Prostate-specific membrane antigen (PSMA)-targeted urea-based inhibitor PMID 33638060
Clinical application: —
Theranostic pair: —

Regulatory status

FDA: —
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: —
Uptake time: —

Reported in the literature. Not a dosing recommendation.

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
—	custom manifold	HPLC	—	96.4 ± 2.2%	PSMA-10 (1) DOTA-conjugated precursor	33638060 2021 EJNMMI Radiopharm Chem

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph: —
USP monograph: —

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityOsmolalityMolar activityMetal impuritiesLu-177m

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Lu-177. Compound class inferred from precursor name (not stated outright) -- PMID 33638060: 'PSMA-10 (1) DOTA-conjugated precursor'.