Tracers / [177Lu]Lu-DOTA-PP-F11N
[177Lu]Lu-DOTA-PP-F11N
Also written as [177Lu]Lu-DOTA-PP-F11N; [Lu-177]Lu-DOTA-PP-F11N
- Radionuclide
- Lu-177 t½ 9585 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- Minigastrin analogue (CCK-2 receptor-targeting peptide) with DOTA chelator
- Target / mechanism
- Cholecystokinin-2 receptor (CCK2R) PMID 36558917
- Clinical application
- Targeted radiotherapy/imaging of CCK2R-expressing tumors, such as Medullary Thyroid Carcinoma (MTC) and Small Cell Lung Cancer (SCLC) PMID 32586246
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | none | >95% | >95% | DOTA-PP-F11N | 36558917 2022 Pharmaceuticals (Basel) |
| Manual synthesis | — | none | >99% | ≥95% | DOTA-PP-F11N | 42477299 2026 EJNMMI Radiopharm Chem After radiolabeling at 90 °C for 15 min, 10 µL of 0.1 M sodium L-ascorbate (in PBS) was added. — 177Lu-Labeling afforded the reference compounds [177Lu]Lu-DOTA-PP-F11N ([177Lu]Lu-2) and [177Lu]Lu-DOTA-CCK-66 ([177Lu]Lu-4) in quantitative radiochemical yields (RCY > 99%) |
| Manual synthesis | — | — | — | — | DOTA-PP-F11N | 32586246 2020 Curr Med Chem Overall 16 patients were enrolled in the study, confirming the safe administration of 200 MBq 111In-DOTA-PP-F11 |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [177Lu]Lu-DOTA-PP-F11N.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with Lu-177. Compound class inferred from precursor name (not stated outright) -- PMID 36558917: 'DOTA-PP-F11N'.