Tracer library / [177Lu]Lu-CTT2001

[177Lu]Lu-CTT2001

Also written as CTT2001; Lu-177 CTT2001; Lu-177-CTT2001

Radionuclide: Lu-177 t½ 9585 min
Modality: Therapy
Production route: —
Stage: Clinical research
Syntheses indexed: 2

Prostate cancer Radiochemistry methodology

What it is

Compound class: PSMA-targeted phosphoramidate inhibitor (irreversible)
Target / mechanism: PSMA (prostate-specific membrane antigen) irreversible phosphoramidate inhibitor PMID 41616583
Clinical application: PSMA-targeted radiotherapeutic for prostate cancer PMID 41616583
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
AllinOne (AiO) Trasis	vendor cassette	none	82-91 not corrected	>97	CTT2001	41616583 2026 Nucl Med Biol automated on a Trasis AllinOne synthesizer - RCYs% ranged from 82% to 91%
AllinOne (AiO) Trasis	vendor cassette	none	86.5 ± 4.27% not corrected	97.6 ± 0.80%	CTT2001	41616583 2026 Nucl Med Biol automated on a Trasis AllinOne synthesizer - producing CTT1403 with a radiochemical yield of 86.5 ± 4.27% (n = 3)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityOsmolalityMetal impuritiesLu-177m

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Lu-177. Stage set/updated at stage 23 from PMID 41616583: 'has previously been evaluated in first-in-human studies'. | Stage 30 (2026-09-18): Stage was 'first-in-human'; normalised to 'Clinical research', original wording kept here.