Tracers / [177Lu]Lu-CTT2001

[177Lu]Lu-CTT2001

Also written as CTT2001; Lu-177 CTT2001; Lu-177-CTT2001
Radionuclide
Lu-177 t½ 9585 min
Modality
Therapy
Production route
—
Stage
first-in-human
Syntheses indexed
2
Prostate cancerRadiochemistry methodology

What it is

Compound class
PSMA-targeted phosphoramidate inhibitor (irreversible)
Target / mechanism
PSMA (prostate-specific membrane antigen) irreversible phosphoramidate inhibitor PMID 41616583
Clinical application
PSMA-targeted radiotherapeutic for prostate cancer PMID 41616583
Theranostic pair
—

Regulatory status

FDA
—
EMA (centralised)
—
Other approvals
—
Brand names
—

Clinical use

Typical injected activity
—
Uptake time
—

Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
AllinOne (AiO)
Trasis
vendor cassettenone82-91
no
>97CTT200141616583
2026 Nucl Med Biol
automated on a Trasis AllinOne synthesizer — RCYs% ranged from 82% to 91%
AllinOne (AiO)
Trasis
vendor cassettenone86.5 ± 4.27%
no
97.6 ± 0.80%CTT200141616583
2026 Nucl Med Biol
automated on a Trasis AllinOne synthesizer — producing CTT1403 with a radiochemical yield of 86.5 ± 4.27% (n = 3)

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
—
USP monograph
—
AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityOsmolalityMetal impuritiesLu-177m
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Lu-177 preparation -> Lu-177m content (rule); therapeutic radiopharmaceutical -> osmolality (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 1 article(s) with Lu-177. Stage set/updated at stage 23 from PMID 41616583: 'has previously been evaluated in first-in-human studies'.