Tracers / [177Lu]Lu-AMBA
[177Lu]Lu-AMBA
Also written as [Lu-177]Lu-AMBA
- Radionuclide
- Lu-177 t½ 9584.6 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- Bombesin(6-14) derivative (GRPR-targeted peptide, AMBA)
- Target / mechanism
- Gastrin-releasing peptide receptor (GRPR) antagonist/agonist ligand PMID 40283887
- Clinical application
- Clinically evaluated GRPR-targeted radioligand therapy comparator PMID 40283887
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | custom manifold | HPLC+SPE | 24-62% yes | >91% | AMBA | 40283887 2025 Pharmaceuticals (Basel) 843–1043 MBq of 177LuCl3 solution was added into a 4 mL glass vial containing 0.7 mL of NaOAc buffer (0.1 M, pH 4.5) and 10 μL precursor solution (1 mM), followed by a 15 min incubation at 95 °C. — The 177Lu-labeled TacsBOMB5, LW01110, LW01142, and AMBA were obtained in 24–62% decay-corrected radiochemical yields |
| — | — | SPE | — | — | AMBA | 20638858 2010 Appl Radiat Isot using the built-in radiodetector of the Tracerlab FX F-N synthesizer to monitor fractionated (68)Ge/(68)Ga generator elution and purification |
| — | — | — | — | — | AMBA | 20638858 2010 Appl Radiat Isot using the built-in radiodetector of the Tracerlab FX F-N synthesizer to monitor fractionated (68)Ge/(68)Ga generator elution and purification |
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Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 2 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 40283887: 'TacsBOMB5, LW01110, LW01142, and AMBA were synthesized following published procedures'.