Tracer library / [131I]PSMA-769-d-tyrosine
[131I]PSMA-769-d-tyrosine
Also written as [I-131]PSMA-769-d-tyrosine
- Radionuclide
- I-131 t½ 11549 min
- Modality
- Therapy
- Production route
- —
- Stage
- Preclinical
- Syntheses indexed
- 1
What it is
- Compound class
- PSMA-targeted Glu-ureido (Lys-urea-Glu) small-molecule inhibitor with Gly-D-Tyr brush border enzyme-cleavable linker
- Target / mechanism
- Prostate-specific membrane antigen (PSMA) inhibitor PMID 29803076
- Clinical application
- detection and treatment of castration-resistant prostate cancer PMID 29803076
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | HPLC+SPE | 45.5 ± 8.5% | >99% | tin precursor d-11 | 29803076 2018 Nucl Med Biol Radioiodinated PSMA-769-d-tyrosine was synthesized similarly from the corresponding tin precursor d-11 - Radioiodinated PSMA-769-d-tyrosine was synthesized similarly from the corresponding tin precursor d-11 in 45.5 ± 8.5% (n = 2) and radiochemical purity of >99%. |
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 29803076. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 29803076: 'tin precursor d-11'. Stage set/updated at stage 39 from PMID 29803076: 'Paired label biodistribution of [125I]12 and [131I]6 was performed in normal mice and in SCID mice bearing both PC3 PIP (PSMA+) and PC3 flu (PSMA-) subcutaneous prostate carcinoma xenografts.'.