Tracer library / [131I]iodine

[131I]iodine

Also written as [I-131]iodine; [I-131]Iodine
Radionuclide
I-131 t½ 11549 min
Modality
Therapy
Production route
—
Stage
—
Syntheses indexed
2
Glioma and brain tumours

What it is

Compound class
—
Target / mechanism
Sodium iodide symporter (NIS)-mediated iodide uptake following gene transfer PMID 36458201
Clinical application
Glioblastoma (GBM) - NIS gene therapy with radioiodide (131I) for tumor treatment PMID 36458201
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Manual synthesis—SPE———36458201
2022 Mol Ther Oncolytics
Briefly, 18F− in H2O (starting activity 6 GBq), trapped on a preconditioned (first 0.9% NaCl [5 mL], then H2O [10 mL]) quaternary methyl ammonium (QMA) ion exchange column
Manual synthesis
n/a
——9098hyaluronic acid (HA) microgels with…hyaluronic acid (HA) microgels with radiolabeling functional groups42574923
2026 J Control Release
absorption-mediated rapid labeling of radioactive iodine-131 (131I) to uniform freeze-dried microgels - high radiolabeling efficiency (> 90% within 10 min)

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. 68 Ga-DOTATATE PET/CT Versus 18 F-FDG PET/CT in TENIS Syndrome: A Head-to-Head Comparison With Elevated and Suppressed TSH Levels in Papillary Thyroid Carcinoma-A Pilot Study.
    2024 · Clin Nucl Med · Prospective
  2. 131I-Anti CD20 radioimmunotherapy of relapsed or refractory non-Hodgkins lymphoma: a phase II clinical trial of a nonmyeloablative dose regimen of chimeric rituximab radiolabeled in a hospital.
    2003 · Cancer Biother Radiopharm · Prospective · Phase II
  3. Selective Use of Radioiodine Therapy in Differentiated Thyroid Carcinoma: A Population-Based Cohort Study.
    2026 · Thyroid · Retrospective
  4. Research on a machine learning method for predicting discharge time of thyroid cancer patients receiving 131I treatment: a retrospective study.
    2025 · Front Physiol · Retrospective
  5. Combination of Stimulated Thyroglobulin and Antithyroglobulin Antibody Predicts the Efficacy and Prognosis of 131I Therapy in Patients With Differentiated Thyroid Cancer Following Total Thyroidectomy: A Retrospective Study.
    2022 · Front Endocrinol (Lausanne) · Retrospective
  6. Incremental diagnostic value of [18F]tetrafluoroborate PET-CT compared to [131I]iodine scintigraphy in recurrent differentiated thyroid cancer.
    2020 · Eur J Nucl Med Mol Imaging · Retrospective
  7. Applying Lean Six Sigma to improve efficiency in outpatient iodine-131 therapy: reducing process time and material waste.
    2026 · BMJ Open Qual · Clinical study
  8. Safety and toxicity of Iopofosine I 131 (CLR 131) with external beam radiation therapy in recurrent or metastatic head and neck cancer: results of a phase 1 single-centre, open-label, single-arm, dose escalation and dose expansion study.
    2025 · EBioMedicine · Clinical study · Phase I
  9. Dependence of radioactive iodine-131 capture by the lacrimal ducts on the tear production level.
    2023 · Indian J Ophthalmol · Clinical study
  10. Probiotic Bacteria Cannot Mitigate the Adverse Effects of Radioactive Iodine-131 Treatment.
    2023 · Cancers (Basel) · Clinical study
Show all 21 clinical studies
  1. Propensity Score Matched Outcome Analysis of Lobar Ablation Versus Completion Thyroidectomy in Low-Risk Differentiated Thyroid Cancer Patients: Median Follow-Up of 11 Years.
    2022 · Thyroid · Clinical study
  2. Effectiveness and Safety of Levothyroxine Tablets Combined with Iodine-131 in the Treatment of Thyroid Cancer.
    2022 · J Oncol · Clinical study
  3. Tissue quantification of radioiodine thyroid uptake in humans by an isotopic imaging technique on slides.
    2021 · Technol Health Care · Clinical study
  4. PSMA PET/CT Identifies Intrapatient Variation in Salivary Gland Toxicity From Iodine-131 Therapy.
    2020 · Mol Imaging · Clinical study
  5. Effect of Radioactive Iodine Treatment on Saliva Rate in the Early Post-treatment Period.
    2020 · J Coll Physicians Surg Pak · Clinical study
  6. Comparison of free thyroxine measurement by chemiluminescence and equilibrium dialysis following 131I therapy in hyperthyroid cats.
    2020 · J Feline Med Surg · Clinical study
  7. [Somatostatin receptor status in non-medullary thyroid carcinoma].
    1999 · Nuklearmedizin · Clinical study
  8. Iodine-131-anti-B1 radioimmunotherapy for B-cell lymphoma.
    1996 · J Clin Oncol · Clinical study · Phase I
  9. Radioiodine Therapy: Alternative for the Treatment of Complicated Thyroid Ectopia.
    2024 · Cureus · Case report
  10. Thyroglobulin as a Rapid and Cost-Effective Biomarker for Diagnosis of Thyroid Carcinoma Brain Metastasis: A Case Report of a Patient with Metastatic Hurthle Cell Thyroid Carcinoma.
    2023 · Am J Case Rep · Case report
  11. Graves disease and metastatic hormonal-active Hürthle cell thyroid cancer: A case report.
    2021 · Medicine (Baltimore) · Case report

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Notes

Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 3 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty.
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