Tracers / [131I]iodine
[131I]iodine
Also written as [I-131]iodine; [I-131]Iodine
- Radionuclide
- I-131 t½ 11549 min
- Modality
- Therapy
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- —
- Target / mechanism
- Sodium iodide symporter (NIS)-mediated iodide uptake following gene transfer PMID 36458201
- Clinical application
- Glioblastoma (GBM) - NIS gene therapy with radioiodide (131I) for tumor treatment PMID 36458201
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | SPE | — | — | — | 36458201 2022 Mol Ther Oncolytics Briefly, 18F− in H2O (starting activity 6 GBq), trapped on a preconditioned (first 0.9% NaCl [5 mL], then H2O [10 mL]) quaternary methyl ammonium (QMA) ion exchange column |
| — | — | — | 90 | 98 | hyaluronic acid (HA) microgels with radiolabeling functional groups | 42574923 2026 J Control Release absorption-mediated rapid labeling of radioactive iodine-131 (131I) to uniform freeze-dried microgels — high radiolabeling efficiency (> 90% within 10 min) |
| — | — | — | — | — | — | 10740654 2000 Cancer Biother Radiopharm |
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Added at stage 21 from therapy-discovered.xlsx (bulk PubMed search by isotope/therapy-type/known-agent, not individually researched yet) -- 3 articles found. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty.