[125I]I-Ex-4

Radionuclide: I-125 t½ 85666 min
Modality: Therapy
Production route: —
Stage: Reported once
Syntheses indexed: 1

What it is

Compound class: Exendin-4 peptide analogue (GLP-1 receptor agonist)
Target / mechanism: GLP-1 receptor (GLP-1R) agonist PMID 40076236
Clinical application: GLP-1R imaging, with hypoglycemia risk particularly relevant in insulinoma patients PMID 40076236
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Manual synthesis	—	HPLC	54%	>99%	Ex-4-C40	40076236 2025 Molecules For radiolabeling peptides, [125I]IPM in acetonitrile was reacted with Ex-D3-C40, Ex-4-C40, or Ex-F1-C40 (100 μg dissolved in PBS) for 30 min at room temperature. - The radiochemical yields for [125I]I-Ex-D3, [125I]I-Ex-4, and [125I]I-Ex-F1 were 43%, 54%, and 59%, respectively

Need this precursor?We can point you to suppliers for [125I]I-Ex-4, or handle the enquiry for you.

Get in touch

Notes

Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 40076236. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 40076236: 'Ex-D3-C40, Ex-4-C40, or Ex-F1-C40 were dissolved in PBS (pH 7.4) and added with IPM (1 eq.) to acetonitrile.'.