Tracer library / [68Ga]PKB3
[68Ga]PKB3
Also written as [Ga-68]Ga-PKB3
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- Reported once
- Syntheses indexed
- 1
What it is
- Compound class
- DOTA-conjugated GRPR-targeting peptide (RM26 analogue)
- Target / mechanism
- Gastrin-releasing peptide receptor (GRPR) antagonist/binder PMID 41701408
- Clinical application
- PET imaging of GRPR-positive tumours as diagnostic counterpart in a 177Lu/68Ga theranostic pair for prostate cancer PMID 41701408
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | — | — | >99% | >97% | PKB3 (DOTA-PEG2-Pip-[MetTrp8, Sar11]RM26) Pepmic Co., Ltd., Suzhou, China | 41701408 2026 EJNMMI Radiopharm Chem The labelling of AU-RM26-M2, PKB2, and PKB3 with Ga-68 was performed by adding 250 µL of freshly eluted Ga-68 (70–80 MBq, measurement after labelling) to a solution containing 5 nmol of peptide, 125 µL EtOH (99.5%), and 30 µL NH4OAc (1 M, pH 4.5). - [68Ga]Ga-PKB2 and [68Ga]Ga-PKB3 were produced with radiochemical yields over 99% |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Pepmic Co., Ltd.
- Typical final purification
- —
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Get in touchNotes
Added at stage 22: promoted from 'Reported once' (single-article, no diagnostic pair at discovery) because a full-text synthesis with extracted data exists in parsed-therapy.xlsx -- PMID(s): 41701408. Target/mechanism, clinical application, indications, approval and precursor fields still need per-agent research and are intentionally left empty. Compound class inferred from precursor name (not stated outright) -- PMID 41701408: 'PKB3 [DOTA-PEG2-Pip-[MetTrp8, Sar11]RM26]'. | Stage 30 (2026-09-18): Modality was 'Therapy' -- a bucket value given to every agent found by the therapy-oriented bulk search (stages 21-22), not a source statement. Corrected to PET: Ga-68 is a positron emitter used only for PET imaging. Linked articles: PMID 41701408.