Tracers / [68Ga]Ga-oxine

[68Ga]Ga-oxine

Also written as [68Ga]Ga-oxine; [68Ga]oxine; [Ga-68]Ga-oxine; [Ga-68]oxine
Radionuclide
Ga-68 t½ 67.71 min
Modality
PET
Production route
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Stage
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Syntheses indexed
2
Dosimetry and biodistribution studies

What it is

Compound class
8-Hydroxyquinoline (oxine) complex - cell/RBC labeling agent
Target / mechanism
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Clinical application
PET/CT imaging of the spleen using gallium-oxine-labeled, heat-damaged red blood cells for differentiation of splenic from non-splenic tissue and diagnosis of splenic anomalies PMID 36766669
Theranostic pair
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Regulatory status

FDA
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EMA (centralised)
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Other approvals
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Brand names
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Clinical use

Typical injected activity
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Uptake time
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Reported in the literature. Not a dosing recommendation.

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Scintomics GRP / GRP-3V
Scintomics
———96.0%8-Hydroxyquinoline (oxine)
Sigma-Aldrich
36766669
2023 Diagnostics (Basel)
The automated synthesis of [68Ga]gallium-oxine was performed on a Scintomics GRP synthesizer (smartGRP module, SCINTOMICS Molecular, Fürstenfeldbruck, Germany)
—————8-hydroxyquinoline36940567
2023 Nucl Med Biol
which was produced from 68Ga and 8-hydroxyquinoline on an automated synthesizer

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMetal impuritiesGe-68 breakthrough
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Ga-68.