Tracer library / [68Ga]Ga-NODAGA-exendin-4

[68Ga]Ga-NODAGA-exendin-4

Also written as [68Ga]Ga-NODAGA-Exendin-4; [Ga-68]Ga-NODAGA-Exendin-4; Exendin-4; Ga-68 Exendin-4; Ga-68 NODAGA-exendin-4; NODAGA-exendin-4
Radionuclide
Ga-68 t½ 67.71 min
Modality
PET
Production route
—
Stage
—
Syntheses indexed
12
Pancreatic beta-cell imaging

What it is

Compound class
Radiolabelled GLP-1-receptor agonist peptide (exendin-4 analogue, NODAGA-conjugated)
Target / mechanism
Glucagon-like peptide-1 receptor (GLP-1R), markedly overexpressed in benign insulinomas PMID 36507990
Clinical application
Localisation of occult insulinomas via GLP-1-receptor imaging PMID 36507990
Theranostic pair
—

Published syntheses

ModuleCassettePurificationYield %RCP %Precursor / supplierSource
Scintomics GRP / GRP-3V
Scintomics
vendor cassetteSPE45 ± 2.4%96.31%NODAGA-exendin-4
piCHEM, Raaba-Grambach, Austria
35056858
2022 Molecules
Scintomics GRP® module, Fürstenfeldbruck, Germany - The mean radiochemical yield was 45 ± 2.4% in all the three validation batches of [68Ga]Ga-NODAGA-exendin-4.
miniAllinOne
Trasis
vendor cassetteSPE67%97%NODAGA[40Lys]-Exendin-4
piCHEM, Raaba-Grambach, Austria
42223859
2026 EJNMMI Radiopharm Chem
automated on the miniAllinOne synthesizer - a radiochemical yield of 67%
miniAllinOne
Trasis
vendor cassetteSPE66 to 67%
n.d.c.; 85 to 87% d.c.
decay-corrected
≥95%Lys40-NODAGA-exendin-4
piCHEM, Raaba-Grambach, Austria
42380410
2026 EJNMMI Radiopharm Chem
All radiosyntheses were carried out on the miniAllinOne synthesiser (operated by the Supervision software, Fig. 2) - confirming that the synthesis proceeded efficiently and provided high radiochemical yields (66 to 67% n.d.c. ; 85 to 87% d.c.).
miniAllinOne
Trasis
vendor cassetteSPE60–65%
RCY = n.d.c. and 76–82% d.c.
decay-corrected
≥95%Lys40-NODAGA-exendin-4
piCHEM, Raaba-Grambach, Austria
42380410
2026 EJNMMI Radiopharm Chem
All radiosyntheses were carried out on the miniAllinOne synthesiser (operated by the Supervision software, Fig. 2) - the measured residual activities and the calculated yields demonstrated the transferability of the automated radiosynthesis regardless of the generator used (RCY = 60–65% n.d.c. and 76–82% d.c.)
miniAllinOne
Trasis
vendor cassetteSPE71–73%
n.d.c.
not corrected
≥95%Lys40-NODAGA-exendin-4
piCHEM, Raaba-Grambach, Austria
42380410
2026 EJNMMI Radiopharm Chem
All radiosyntheses were carried out on the miniAllinOne synthesiser (operated by the Supervision software, Fig. 2) - the addition of this protective agent enabled highest ever reported non-decay-corrected synthesis yields of 71–73%.
miniAllinOne
Trasis
vendor cassetteSPE66 to 67%
n.d.c.; 85 to 87% d.c.
decay-corrected
≥95%Lys40-NODAGA-exendin-4
piCHEM, Raaba-Grambach, Austria
42380410
2026 EJNMMI Radiopharm Chem
All radiosyntheses were carried out on the miniAllinOne synthesiser (operated by the Supervision software, Fig. 2) - confirming that the synthesis proceeded efficiently and provided high radiochemical yields (66 to 67% n.d.c. ; 85 to 87% d.c.)
miniAllinOne
Trasis
vendor cassetteSPE60–65%
n.d.c. and 76–82% d.c.
decay-corrected
≥95%Lys40-NODAGA-exendin-4
piCHEM, Raaba-Grambach, Austria
42380410
2026 EJNMMI Radiopharm Chem
All radiosyntheses were carried out on the miniAllinOne synthesiser (operated by the Supervision software, Fig. 2) - the calculated yields demonstrated the transferability of the automated radiosynthesis regardless of the generator used (RCY = 60–65% n.d.c. and 76–82% d.c.)
miniAllinOne
Trasis
vendor cassetteSPE71–73%
not corrected
—Lys40-NODAGA-exendin-4
piCHEM, Raaba-Grambach, Austria
42380410
2026 EJNMMI Radiopharm Chem
All radiosyntheses were carried out on the miniAllinOne synthesiser (operated by the Supervision software, Fig. 2) - the addition of this protective agent enabled highest ever reported non-decay-corrected synthesis yields of 71–73%
miniAllinOne
Trasis
vendor cassetteSPE67%97%NODAGA-Exendin(40Lys)-4
piCHEM, Raaba-Grambach, Austria
42223859
2026 EJNMMI Radiopharm Chem
automated on the miniAllinOne synthesizer - with a mean radiochemical purity of 97% and a radiochemical yield of 67%
Manual synthesis—SPE—>95%NODAGA-exendin-4
piCHEM, Raaba-Grambach, Austria
37265006
2023 Mol Pharm
labeled with 68Ga by adding 2.5 M HEPES
Scintomics GRP / GRP-3V
Scintomics
vendor cassetteSPE——NODAGA-exendin-4
piCHEM, Raaba-Grambach, Austria
35889351
2022 Molecules
the automated synthesis module Scintomics GRPTM (Scintomics GmbH, Fürstenfeldbruck, Germany)
Scintomics GRP / GRP-3V
Scintomics
—SPE23.53 ± 2.4%91.69%[Lys40,Nle14(Ahx-NODAGA)NH2]exendin-433687908
2022 Curr Radiopharm
eluted with 0.1M HCl on an automated synthesis module (Scintomics GRP®) - getting the best radiochemical yield (23.53 ± 2.4%)

Clinical literature

Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.

  1. Glucagon-like peptide-1 receptor PET/CT with 68Ga-exendin-4 for localizing insulinoma: a real-world, single-center study.
    2025 · Eur J Nucl Med Mol Imaging · Prospective, retrospective
  2. Outcomes of 68Ga-NODAGA-Exendin-4 PET/CT Guided Surgical Management of Insulinomas in MEN1: A Preliminary Study.
    2025 · Nuklearmedizin · Retrospective
  3. Outcomes of 68Ga-NODAGA-Exendin-4 PET/CT Guided Surgical Management of Insulinomas in MEN1: A Preliminary Study.
    2025 · Horm Metab Res · Retrospective
  4. Structural determinants of beta-cell failure in type 2 diabetes: a multimodality imaging study.
    2026 · Metabolism · Clinical study
  5. Beta cell function and mass in individuals with and without remission of type 2 diabetes after Roux-en-Y gastric bypass.
    2026 · Diabetologia · Clinical study
  6. Localization of Benign Insulinomas With a Radionuclide Tracer Targeting the GLP-1 Receptor With Pegylated Exendin-4.
    2026 · J Clin Endocrinol Metab · Clinical study
  7. Insulin Autoimmune Syndrome: Imaging Findings and Uptake Pattern With 68 Ga-Exendin-4 and 68 Ga-DOTATATE PET-CT.
    2026 · Clin Nucl Med · Clinical study
  8. Does X mark the spot? A case series of discrepant preoperative insulinoma localization.
    2025 · Endocrinol Diabetes Metab Case Rep · Clinical study
  9. Intense Uptake of 68 Ga-exendin-4 in a Patient With WHO Grade 3 Insulinoma and Extensive Intrahepatic Metastases.
    2025 · Clin Nucl Med · Clinical study
  10. Activation of the HPA Axis Does Not Explain Nonresponsiveness to GLP-1R Agonist Treatment in Individuals With Type 2 Diabetes.
    2025 · Diabetes · Clinical study
Show all 14 clinical studies
  1. Monitoring β-Cell Survival After Intrahepatic Islet Transplantation Using Dynamic Exendin PET Imaging: A Proof-of-Concept Study in Individuals With Type 1 Diabetes.
    2023 · Diabetes · Clinical study
  2. Importance of beta cell mass for glycaemic control in people with type 1 diabetes.
    2023 · Diabetologia · Clinical study
  3. Glucagonlike Peptide-1 Receptor Imaging in Individuals with Type 2 Diabetes.
    2022 · J Nucl Med · Clinical study
  4. Morphologically 'invisible' proinsulin - secreting adenoma detected by Ga-68 Exendin-4 (GLP-1 Receptor) positron emission tomography/CT.
    2018 · J Med Imaging Radiat Oncol · Case report

Precursor

Common precursor
—
Suppliers seen in the literature
—
Cited suppliers in indexed syntheses
piCHEM
Typical final purification
—

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph
not verified No Ph. Eur. check is recorded for this entry.
USP monograph
not verified No USP check is recorded for this entry.
AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 3 article(s) with Ga-68.
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