Tracers / [68Ga]Ga-DOTA-Siglec-9
[68Ga]Ga-DOTA-Siglec-9
Also written as [68Ga]Ga-DOTA-Siglec-9; [Ga-68]Ga-DOTA-Siglec-9
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- DOTA-conjugated Siglec-9-binding peptide
- Target / mechanism
- Siglec-9 receptor, binds sialic acid residues on glycoproteins involved in immune cell trafficking and inflammation; related to VAP-1 interaction PMID 41114859
- Clinical application
- PET imaging of chronic inflammatory diseases, autoimmune disorders, and cancer (VAP-1/Siglec-9 related pathological conditions) PMID 41114859
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | 55.04% no | 99.48% | DOTA-Siglec-9 ABX | 41114859 2025 EJNMMI Radiopharm Chem Radiolabelling was conducted using the GRP module 3 V automated synthesis platform (Scintomics GRP®, Fürstenfeldbruck, Germany). — [⁶⁸Ga]Ga-DOTA-Siglec-9 was successfully synthesized with a radiochemical yield (RY) of 55.04% |
| — | — | — | — | — | — | 42018345 2026 Clin Exp Rheumatol |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DOTA-Siglec-9.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 41114859: 'DOTA-Siglec-9'.