Tracer library / [68Ga]Ga-DOTA-Siglec-9
[68Ga]Ga-DOTA-Siglec-9
Also written as [68Ga]Ga-DOTA-Siglec-9; [Ga-68]Ga-DOTA-Siglec-9
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 1
What it is
- Compound class
- DOTA-conjugated Siglec-9-binding peptide
- Target / mechanism
- Siglec-9 receptor, binds sialic acid residues on glycoproteins involved in immune cell trafficking and inflammation; related to VAP-1 interaction PMID 41114859
- Clinical application
- PET imaging of chronic inflammatory diseases, autoimmune disorders, and cancer (VAP-1/Siglec-9 related pathological conditions) PMID 41114859
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Scintomics GRP / GRP-3V Scintomics | vendor cassette | SPE | 55.04% not corrected | 99.48% | DOTA-Siglec-9 ABX | 41114859 2025 EJNMMI Radiopharm Chem Radiolabelling was conducted using the GRP module 3 V automated synthesis platform (Scintomics GRP®, Fürstenfeldbruck, Germany). - [⁶⁸Ga]Ga-DOTA-Siglec-9 was successfully synthesized with a radiochemical yield (RY) of 55.04% |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DOTA-Siglec-9.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 41114859: 'DOTA-Siglec-9'. Stage set/updated at stage 39 from PMID 41114859: 'This study aimed to develop a new automated radiolabelling protocol for the preparation of [⁶⁸Ga]Ga-DOTA-Siglec-9 for clinical use.'.