Tracer library / [68Ga]Ga-DO3A-VS-Cys40-Exendin-4
[68Ga]Ga-DO3A-VS-Cys40-Exendin-4
Also written as [68Ga]Ga-DO3A-VS-Cys40-Exendin-4; [68Ga]Ga-DO3A-VS-Cys40-Exendin-4/PET; [Ga-68]Ga-DO3A-VS-Cys40-Exendin-4; [Ga-68]Ga-DO3A-VS-Cys40-Exendin-4/PET
- Radionuclide
- Ga-68 t½ 67.71 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 1
What it is
- Compound class
- DO3A-conjugated exendin-4 peptide (GLP-1 receptor agonist peptide radiotracer)
- Target / mechanism
- Glucagon-like peptide-1 receptor (GLP-1R) PMID 28721305
- Clinical application
- PET/CT imaging of GLP-1 receptor for detection of insulinomas and study of pancreatic GLP-1R in type 2 diabetes PMID 28721305
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Modular-Lab (model not stated) | — | HPLC | 43±2% not corrected | >90% | DO3A-VS-Cys40-Exendin-4 | 28721305 2017 Am J Nucl Med Mol Imaging synthesis platform, and disposable cassettes for 68Ga-labelling used in the study was purchased from Eckert & Ziegler - The non-decay corrected radiochemical yield was 43±2% |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [68Ga]Ga-DO3A-VS-Cys40-Exendin-4.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with Ga-68. Compound class inferred from precursor name (not stated outright) -- PMID 28721305: 'DO3A-VS-Cys40-Exendin-4'.