Tracer library / [68Ga]Ga-ABY-025

[68Ga]Ga-ABY-025

Also written as [68Ga]Ga-ABY-025; [68Ga]Ga-ABY-025/PET; [Ga-68]Ga-ABY-025; [Ga-68]Ga-ABY-025/PET

Radionuclide: Ga-68 t½ 67.71 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Breast cancer Receptor expression phenotyping

What it is

Compound class: Radiolabelled affibody molecule (engineered Z-domain scaffold protein, ~7 kDa)
Target / mechanism: Human epidermal growth factor receptor 2 (HER2) PMID 26877784
Clinical application: Whole-body quantification of HER2 expression in metastatic breast cancer PMID 26877784
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
Modular-Lab PharmTracer	—	—	—	98.7 ± 0.6%	ABY-025	30911434 2019 Am J Nucl Med Mol Imaging implemented on the Modular-Lab PharmTrace synthesis platform (Eckert & Ziegler)
Modular-Lab PharmTracer Eckert & Ziegler	vendor cassette	SPE	44 ± 2% decay-corrected	98 ± 1%	ABY-025 (ZHER2:2891-Cys-MMA-DOTA) Affibody AB	37991639 2023 EJNMMI Radiopharm Chem [68Ga]Ga-ABY-025 was produced on a synthesis module, Modular-Lab PharmTracer (Eckert & Ziegler) - With a decay corrected radiochemical yield of 44 ± 2%

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: Affibody AB
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrityMolar activityMetal impuritiesGe-68 breakthrough

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); radiometal tracer -> metal impurities (rule); Ga-68, generator production assumed (no synthesis data found) -> Ge-68 breakthrough (preliminary); receptor ligand with a saturable target -> molar activity (rule)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with Ga-68.