Tracers / [18F]VM4-037

[18F]VM4-037

Also written as [18F]VM4-037; [F-18]VM4-037; VM4-037
Radionuclide
F-18 t½ 109.7 min
Modality
PET
Production route
Cyclotron liquid target
Stage
Research
Syntheses indexed
0
Renal cell carcinomaTumour hypoxia

What it is

Compound class
Sulfonamide
Target / mechanism
Carbonic anhydrase IX (CAIX) PMID 24696183 / DOI 10.1007/s11307-014-0730-7; PMID 25708744 / DOI 10.1007/s11307-015-0831-y
Clinical application
PET imaging of carbonic anhydrase IX (CAIX) expression in tumours (studied in renal cell carcinoma; high liver/kidney background limits use) PMID 24696183 / DOI 10.1007/s11307-014-0730-7; PMID 25708744 / DOI 10.1007/s11307-015-0831-y
Theranostic pair
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Regulatory status

FDA
No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=VM4-037
EMA (centralised)
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Other approvals
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Brand names
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Clinical use

Typical injected activity
584 +/- 143 MBq (range 401-728 MBq) PMID 24696183 / DOI 10.1007/s11307-014-0730-7
Uptake time
Whole-body PET series ~11-133 min post-injection (~1 h data used) PMID 24696183 / DOI 10.1007/s11307-014-0730-7

Reported in the literature. Not a dosing recommendation.

Published syntheses

No synthesis has been parsed for this agent yet.

Precursor

Common precursor
VM4-037 precursor 1 (nucleophilic [18F]fluorination in acetonitrile) PMID 24696183 / DOI 10.1007/s11307-014-0730-7
Suppliers seen in the literature
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Typical final purification
HPLC

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Quality control Preliminary — inferred from compound class

Ph. Eur. monograph
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USP monograph
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AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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