Tracer library / [18F]VM4-037

Structure of VM4-037 (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 59552698

[18F]VM4-037

Also written as [18F]VM4-037; [F-18]VM4-037; VM4-037

Radionuclide: F-18 t½ 109.7 min
Modality: PET
Production route: Cyclotron liquid target
Stage: Research
Syntheses indexed: 0

Renal cell carcinoma Tumour hypoxia

What it is

Compound class: Sulfonamide
Target / mechanism: Carbonic anhydrase IX (CAIX) PMID 24696183 / DOI 10.1007/s11307-014-0730-7; PMID 25708744 / DOI 10.1007/s11307-015-0831-y
Clinical application: PET imaging of carbonic anhydrase IX (CAIX) expression in tumours (studied in renal cell carcinoma; high liver/kidney background limits use) PMID 24696183 / DOI 10.1007/s11307-014-0730-7; PMID 25708744 / DOI 10.1007/s11307-015-0831-y
Theranostic pair: —

Regulatory status

FDA: No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=VM4-037
EMA (centralised): —
Other approvals: —
Brand names: —

Clinical use

Typical injected activity: 584 +/- 143 MBq (range 401-728 MBq) PMID 24696183 / DOI 10.1007/s11307-014-0730-7
Uptake time: Whole-body PET series ~11-133 min post-injection (~1 h data used) PMID 24696183 / DOI 10.1007/s11307-014-0730-7

Reported in the literature. Not a dosing recommendation.

Published syntheses

No synthesis has been parsed for this agent yet.

Precursor

Common precursor: VM4-037 precursor 1 (nucleophilic [18F]fluorination in acetonitrile) PMID 24696183 / DOI 10.1007/s11307-014-0730-7
Suppliers seen in the literature: —
Typical final purification: HPLC

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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