Tracers / [18F]T807
[18F]T807
Also written as [18F]AV-1451; [18F]AV1451; [18F]Flortaucipir; [18F]T807; [F-18]AV-1451; [F-18]AV1451; [F-18]Flortaucipir
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Approved
- Syntheses indexed
- 9
What it is
- Compound class
- Radiolabelled carbazole/pyridoindole derivative (tau-binding small molecule)
- Target / mechanism
- Aggregated tau protein (paired helical filaments) FDA label NDA212123
- Clinical application
- PET imaging of the brain to estimate the density and distribution of aggregated tau neurofibrillary tangles in adults being evaluated for Alzheimer's disease FDA label NDA212123
- Theranostic pair
- —
Regulatory status
- FDA
- 2020, Tauvid, Avid Radiopharmaceuticals (Eli Lilly) FDA (Drugs@FDA/openFDA): NDA212123, approved 2020-05-28
- EMA (centralised)
- 2024, Tauvid, Eli Lilly EMA medicines register export (2026-09-09): EMEA/H/C/006064, 'Authorised', authorised 22 Aug 2024
- Other approvals
- —
- Brand names
- Tauvid
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | — | — | 28241163 2017 JAMA Neurol |
| TRACERlab FX FN GE HealthCare | fixed tubing | HPLC+SPE | 14% no | 98 ± 1% | N-Boc-protected nitro-precursor Huayi | 29503848 2017 EJNMMI Radiopharm Chem An optimized [18F]AV1451 synthesis using a TRACERLab FXFN module — 202 ± 57 mCi at end-of-synthesis (EOS) (14% based on starting [18F]fluoride) |
| TRACERlab FX FN GE HealthCare | — | HPLC+SPE | 14 ± 3% no | >95% | tert-butyl 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole-5-carboxylate (1b) Huayi | 24339014 2013 J Labelled Comp Radiopharm GE Tracerlab™ FXFN radiosynthesis module — The uncorrected RCY of [18F]T807 was 14 ± 3% (n = 3) |
| TRACERlab FX FN GE HealthCare | — | HPLC+SPE | 2.4% no | — | 7-(6-nitropyridin-3-yl)-5H-pyrido[4,3-b]indole (1a) Huayi | 24339014 2013 J Labelled Comp Radiopharm GE Tracerlab™ FXFN radiosynthesis module — The uncorrected radiochemical yield was much lower (2.4%; n = 1) |
| Synthra RNplus | — | HPLC+SPE | 14.8-16.6% no | >99.9% | AV1622 | 34234995 2021 Am J Nucl Med Mol Imaging an automated radiosynthesis of [18F]Flortaucipir in a RNplus Research module — The final products were obtained in non-decay corrected radiochemical yields of 14.8-16.6% (n = 3) within total synthesis time of 55 min. |
| — | — | — | 27% no | >99% | — | 31083778 2019 J Labelled Comp Radiopharm synthesized and formulated using an automated radiosynthesis module — nondecay corrected radiochemical yields of 27% and 29% (relative [18 F]F- ), respectively |
| — | — | — | 5-10% yes | — | T807P | 26048805 2015 Bioorg Med Chem Lett through manual synthesis with 5-10% decay corrected radiochemical yield in two steps — 5-10% decay corrected radiochemical yield in two steps |
| — | — | HPLC+SPE | 20-30% yes | — | t-Boc-protected T807P | 26048805 2015 Bioorg Med Chem Lett in a home-built automated [(18)F]radiosynthesis module with 20-30% decay corrected radiochemical yield in one step — 20-30% decay corrected radiochemical yield in one step |
| — | — | HPLC | 5 ± 1% no | ≥ 99% | — | 25248283 2014 Mol Imaging adapted to suit a commercial microfluidic flow chemistry module. For this proof of concept, the flow system was integrated to a GE Tracerlab FXFN unit for high-performance liquid chromatography purification and formulation. — an overall uncorrected radiochemical yield of 5 ± 1% (n = 3), relative to starting [18F]fluoride (end of bombardment) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]T807.
Get in touchNotes
Added from reverse module search (stage 6); 12 article(s) with F-18.