Tracers / [18F]SynVesT-1
[18F]SynVesT-1
Also written as [18F]MNI-1126; [18F]SDM-8; [18F]SynVesT-1; [F-18]SynVesT-1; SynVesT-1
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- SV2A-targeting small molecule PET tracer (trimethyltin/stannyl precursor-derived aromatic fluorinated compound)
- Target / mechanism
- Binds synaptic vesicle glycoprotein 2A (SV2A), a 12-pass transmembrane protein in presynaptic vesicles PMID 42451763
- Clinical application
- PET imaging of SV2A (synaptic density) for neuropsychiatric and neurodegenerative disease research and human use PMID 39254802
- Theranostic pair
- —
Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | custom manifold | HPLC | 47±5 | — | stannyl precursor 9 | 36214204 2023 Chemistry Optimized procedure for radiofluorination of stannyl precursors: [18F]F− was loaded onto a QMA carbonate cartridge — furnished the tracer in RCCs of 47±5 % (Scheme 3) |
| AllinOne (AiO) Trasis | custom manifold | HPLC | 20.6 ± 1.2% yes | >99% | Me3Sn-SDM-8 Provided by Huashan hospital | 39254802 2024 EJNMMI Radiopharm Chem Utilizing the Trasis AllinOne-36 (AIO) module, we’ve automated synthesis to Good Manufacturing Practice (GMP) standards — [18F] SynVesT-1 was obtained with consistently high radiochemical yields (RCY) of 20.6 ± 1.2% (the decay-corrected RCY, n = 3) at end of synthesis |
| AllinOne (AiO) Trasis | custom manifold | HPLC | 30-37 yes | >98% | trimethyltin precursor 1 ABX | 42451763 2026 Molecules the Trasis All-in-One (AIO) module — affording a superior overall decay-corrected radiochemical yield (30–37% vs. 20.6 ± 1.2%) |
| — | — | — | 19.5 ± 0.5% | >98% | — | 36044030 2022 J Labelled Comp Radiopharm The procedure was developed and established on a commercially available module, TracerMaker (ScanSys Laboratorieteknik ApS, Copenhagen, Denmark), a synthesis platform originally developed to conduct carbon-11 radiochemistry. — which corresponds to a radiochemical yield (RCY) of 19.5 ± 0.5% |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with F-18. Stage 17: confirmed MNI-1126/SDM-8 are former names of this same compound (J Nucl Med 2022;63(suppl 2):2959; Mol Imaging Biol renaming report) — kept. Removed 'UCB-J' from Alternative names: UCB-J is a separate, non-fluorinated compound (SynVesT-1 was designed as an 18F analogue diverging from it), not a synonym; no stray MNI-1126/SDM-8 rows exist elsewhere to merge. Compound class inferred from precursor name (not stated outright) -- PMID 42451763: 'trimethyltin precursor 1'.