Tracer library / [18F]SynVesT-1
[18F]SynVesT-1
Also written as [18F]MNI-1126; [18F]SDM-8; [18F]SynVesT-1; [F-18]SynVesT-1; SynVesT-1
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 4
What it is
- Compound class
- SV2A-targeting small molecule PET tracer (trimethyltin/stannyl precursor-derived aromatic fluorinated compound)
- Target / mechanism
- Binds synaptic vesicle glycoprotein 2A (SV2A), a 12-pass transmembrane protein in presynaptic vesicles PMID 42451763
- Clinical application
- PET imaging of SV2A (synaptic density) for neuropsychiatric and neurodegenerative disease research and human use PMID 39254802
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Manual synthesis | custom manifold | HPLC | 47±5 | — | stannyl precursor 9 | 36214204 2023 Chemistry Optimized procedure for radiofluorination of stannyl precursors: [18F]F− was loaded onto a QMA carbonate cartridge - furnished the tracer in RCCs of 47±5 % (Scheme 3) |
| AllinOne (AiO) Trasis | custom manifold | HPLC | 20.6 ± 1.2% decay-corrected | >99% | Me3Sn-SDM-8 Provided by Huashan hospital | 39254802 2024 EJNMMI Radiopharm Chem Utilizing the Trasis AllinOne-36 (AIO) module, we’ve automated synthesis to Good Manufacturing Practice (GMP) standards - [18F] SynVesT-1 was obtained with consistently high radiochemical yields (RCY) of 20.6 ± 1.2% (the decay-corrected RCY, n = 3) at end of synthesis |
| AllinOne (AiO) Trasis | custom manifold | HPLC | 30-37 decay-corrected | >98% | trimethyltin precursor 1 ABX | 42451763 2026 Molecules the Trasis All-in-One (AIO) module - affording a superior overall decay-corrected radiochemical yield (30–37% vs. 20.6 ± 1.2%) |
| TracerMaker Scansys Laboratorieteknik | — | — | 19.5 ± 0.5% | >98% | — | 36044030 2022 J Labelled Comp Radiopharm The procedure was developed and established on a commercially available module, TracerMaker (ScanSys Laboratorieteknik ApS, Copenhagen, Denmark), a synthesis platform originally developed to conduct carbon-11 radiochemistry. - which corresponds to a radiochemical yield (RCY) of 19.5 ± 0.5% |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX, Provided by Huashan hospital
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]SynVesT-1.
Get in touchNotes
Added from reverse module search (stage 6); 3 article(s) with F-18. Stage 17: confirmed MNI-1126/SDM-8 are former names of this same compound (J Nucl Med 2022;63(suppl 2):2959; Mol Imaging Biol renaming report) — kept. Removed 'UCB-J' from Alternative names: UCB-J is a separate, non-fluorinated compound (SynVesT-1 was designed as an 18F analogue diverging from it), not a synonym; no stray MNI-1126/SDM-8 rows exist elsewhere to merge. Compound class inferred from precursor name (not stated outright) -- PMID 42451763: 'trimethyltin precursor 1'.