Tracers / [18F]PBR102
[18F]PBR102
Also written as [18F]PBR102; [F-18]PBR102
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- preclinical
- Syntheses indexed
- 2
What it is
- Compound class
- imidazopyridine (fluoroethoxy-substituted 2-(6-chloro-2-phenyl)imidazo[1,2-a]pyridin-3-yl)-N,N-diethylacetamide)
- Target / mechanism
- 18-kDa translocator protein (TSPO) / peripheral benzodiazepine receptor (PBR) PMID 25231248
- Clinical application
- Neuroinflammation (preclinical model) PMID 22300959
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | 30±2% no | >99% | p-toluenesulfonyl precursors | 21852142 2012 Appl Radiat Isot radiosynthesis of [(18)F]PBR111 and [(18)F]PBR102 in the Tracerlab FX(FN) — 30±2% radiochemical yield non-decay-corrected for both tracers |
| — | — | — | 25±2% no | >99% | p-toluenesulfonyl precursors | 21852142 2012 Appl Radiat Isot Tracerlab MX(FDG) (25±2% radiochemical yield non-decay-corrected for both tracers) — Tracerlab MX(FDG) (25±2% radiochemical yield non-decay-corrected for both tracers) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]PBR102.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.