Tracers / [18F]MC225
[18F]MC225
Also written as [18F]MC225; [F-18]MC225
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- P-gp PET tracer (tetrahydroisoquinoline derivative)
- Target / mechanism
- P-glycoprotein (P-gp) function at the blood-brain barrier PMID 34264435
- Clinical application
- —
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| Synthera IBA | vendor cassette | HPLC+SPE | 6.53 yes | 97.14 | MC225 mesylate precursor | 34264435 2021 EJNMMI Radiopharm Chem IBA Synthera Synthesis Module — 6.53 ± 3 |
| Modular-Lab PharmTracer Eckert & Ziegler | custom manifold | HPLC+SPE | 3.76 yes | 91.70 | MC225 mesylate precursor | 34264435 2021 EJNMMI Radiopharm Chem the Modular Lab PharmTracer from Eckert & Ziegler (Fig. 6) — 3.76 ± 2 |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]MC225.
Get in touchNotes
Added from reverse module search (stage 6); 1 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 34264435: '6,7-dimethoxy-2-(3-(5-(2-((methylsulfonyl)oxy)ethoxy)-1,2,3,4-tetrahydronaphthalen-1-yl)propyl)-1,2,3,4-tetrahydroisoquinolin-2-ium methanesulfonate (8) MC225 precursor'.