Tracer library / [18F]JK-PSMA-7
[18F]JK-PSMA-7
Also written as (((S)-1-carboxy-5-(6-([18F]fluoro)-2-methoxynicotinamido)pentyl)carbamoyl)-L-glutamic acid; [18F]JK-PSMA-7; [18F]JK-PSMA7; [F-18]JK-PSMA-7; [F-18]JK-PSMA7
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- Urea-based PSMA-targeting small molecule (Lys-urea-Glu inhibitor)
- Target / mechanism
- Prostate-specific membrane antigen (PSMA) inhibitor PMID 34370181
- Clinical application
- PET imaging of PSMA expression in prostate cancer and investigational use in soft tissue sarcoma PMID 39861180
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | vendor cassette | HPLC+SPE | 58% not corrected | >99% | 5-(((S)-6-(tert-butoxy)-5-(3-((S)-1,5-di-ter…5-(((S)-6-(tert-butoxy)-5-(3-((S)-1,5-di-tert-butoxy-1,5-dioxopentan-2-yl)ureido)-6-oxohexyl)carbamoyl)-6-methoxy-N,N,N-trimethylpyridin-2-ammonium triflate (5) Trasis | 39861180 2025 Pharmaceuticals (Basel) the versatile cassette-based Trasis AllinOne (AIO) synthesizer - The total activity yield of [18F]JK-PSMA-7 ([18F]4) obtained using the AIO system was 38.9 ± 4.0% (n = 260; radiochemical yield of 58%) |
| Manual synthesis | — | — | — | — | — | 34370181 2022 Mol Imaging Biol [68Ga]Ga-PSMA-11 and [18F]F-JK-PSMA-7 were labeled according to standard protocols, which have been published elsewhere [18]. |
Clinical literature
Clinical studies in the indexed corpus, ordered by design (multicentre, prospective, retrospective, others, case reports last) and then by year. Titles and links only, as published; this is not a summary of the evidence.
- PSMA expression and PSMA PET/CT imaging in metastatic soft tissue sarcoma patients, results of a prospective study.2025 · Eur J Nucl Med Mol Imaging · Prospective
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- Trasis
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); receptor ligand with a saturable target -> molar activity (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]JK-PSMA-7.
Get in touchNotes
Added from reverse module search (stage 6); 5 article(s) with F-18. | Stage 28: added indication(s) onc-sarcoma from consolidated missing-rubric review.