Tracer library / [18F]HX4
[18F]HX4
Also written as [18F]HX4; [F-18]HX4
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Clinical research
- Syntheses indexed
- 1
What it is
- Compound class
- 2-nitroimidazole derivative
- Target / mechanism
- —
- Clinical application
- Tumour hypoxia imaging PMID 25725983
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| TRACERlab MX GE HealthCare | — | HPLC | 12 ± 3% not corrected | — | nosylate | 25725983 2015 Nucl Med Biol A two-step, one-pot synthetic procedure was developed on a GE Tracerlab MX-FDG with a disposable cassette. - GMP compliant [(18)F]HX4 was produced in non-decay corrected radiochemical yields of 12 ± 3% (n = 9) in 55 min including HPLC purification. |
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
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Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18. Stage set/updated at stage 39 from PMID 25725983: '[(18)F]HX4 is a 2-nitroimidazole based investigational radiotracer for imaging hypoxia.'.