Tracers / [18F]GE-226
[18F]GE-226
Also written as [18F]GE-226; [F-18]GE-226; GE-226; GEH121224
- Radionuclide
- F-18 t½ 109.7 min
- Modality
- PET
- Production route
- Cyclotron liquid target
- Stage
- Research
- Syntheses indexed
- 1
What it is
- Compound class
- —
- Target / mechanism
- HER2 (human epidermal growth factor receptor 2); HER2-binding Affibody molecule ZHER2:2891 PMID 31339589 / DOI 10.1002/jlcr.3789; PMID 24493830 / DOI 10.1158/1078-0432.CCR-13-2421
- Clinical application
- PET imaging of HER2 expression / HER2-positive tumour lesions (recurrent metastatic breast cancer; pharmacodynamic response to HER2-modulating therapy) PMID 24493830 / DOI 10.1158/1078-0432.CCR-13-2421; PMID 31339589 / DOI 10.1002/jlcr.3789
- Theranostic pair
- —
Regulatory status
- FDA
- No Drugs@FDA / openFDA drug registry — no approved application found; search: https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=BasicSearch.process&searchTerm=GE-226
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | SPE | 30% ± 7 | 94% ± 2 | Affibody molecule ZHER2:2891 | 31339589 2019 J Labelled Comp Radiopharm we have developed and optimised a full protocol for the automated GE FASTlab synthesiser — activity yield of 30% ± 7 (n = 18) |
Precursor
- Common precursor
- Affibody molecule ZHER2:2891, conjugated with [18F]4-fluorobenzaldehyde ([18F]FBA prosthetic group) PMID 31339589 / DOI 10.1002/jlcr.3789
- Suppliers seen in the literature
- —
- Typical final purification
- SPE
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]GE-226.
Get in touchNotes
Target and application not filled - to be taken from the publication.