Tracers / [18F]FSW-100
[18F]FSW-100
Also written as [18F]FSW-100; [F-18]FSW-100
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- HDAC6 radioligand (brain-penetrating small molecule)
- Target / mechanism
- Histone deacetylase 6 (HDAC6) PMID 38831171
- Clinical application
- Brain PET imaging of HDAC6 for proteinopathies PMID 38831171
- Theranostic pair
- —
Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| CFN-MPS200 Sumitomo | — | HPLC+SPE | 11.5 ± 1.6 | greater than 95% | arylboronic precursor of FSW-100 BioDuro, San Diego, CA | 38831171 2024 EJNMMI Radiopharm Chem This study was carried out using a CFN-MPS200 synthesiser (Sumitomo Heavy Industries). — RCY was 11.5 ± 1.6% and the activity yield was 3303 ± 413 MBq |
| COSMiC-Mini NMP Business Support | — | HPLC | 49.0 ± 5.8 | — | arylboronic precursor of FSW-100 BioDuro, San Diego, CA | 38831171 2024 EJNMMI Radiopharm Chem 18F-Fluorination reaction studies were performed using a COSMiC-Mini radiosynthesiser (NMP Business Support, Sanda, Japan). — This reaction condition gave the 18F-intermediate with a non-isolated RCY of 49.0 ± 5.8% (entry 1). |
| — | — | — | 12% | — | — | 38441662 2024 Eur J Nucl Med Mol Imaging Three consecutive validation runs of the automated radiosynthesis gave [18F]FSW-100 injections — radiochemical yields of 12% |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FSW-100.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18.