Tracer library / [18F]FSW-100

[18F]FSW-100

Also written as [18F]FSW-100; [F-18]FSW-100

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: Preclinical
Syntheses indexed: 2

Alzheimer's disease CNS receptor and transporter imaging

What it is

Compound class: HDAC6 radioligand (brain-penetrating small molecule)
Target / mechanism: Histone deacetylase 6 (HDAC6) PMID 38831171
Clinical application: Brain PET imaging of HDAC6 for proteinopathies PMID 38831171
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
CFN-MPS200 Sumitomo	—	HPLC+SPE	11.5 ± 1.6	>95%	arylboronic precursor of FSW-100 BioDuro, San Diego, CA	38831171 2024 EJNMMI Radiopharm Chem This study was carried out using a CFN-MPS200 synthesiser (Sumitomo Heavy Industries). - RCY was 11.5 ± 1.6% and the activity yield was 3303 ± 413 MBq
COSMiC-Mini NMP Business Support	—	HPLC	49.0 ± 5.8	—	arylboronic precursor of FSW-100 BioDuro, San Diego, CA	38831171 2024 EJNMMI Radiopharm Chem 18F-Fluorination reaction studies were performed using a COSMiC-Mini radiosynthesiser (NMP Business Support, Sanda, Japan). - This reaction condition gave the 18F-intermediate with a non-isolated RCY of 49.0 ± 5.8% (entry 1).

Precursor

Common precursor: —
Suppliers seen in the literature: —
Cited suppliers in indexed syntheses: BioDuro
Typical final purification: —

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. Stage set/updated at stage 39 from PMID 38441662: 'As a mandatory step prior to clinical translation, we performed preclinical validation of [18F]FSW-100.'.