Tracers / [18F]FP-TZTP
[18F]FP-TZTP
Also written as [18F]FP-TZTP; [F-18]FP-TZTP
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 2
What it is
- Compound class
- M2 selective muscarinic acetylcholine receptor agonist radioligand
- Target / mechanism
- Muscarinic acetylcholine receptor subtype 2 (M2) PMID 19186063
- Clinical application
- Aging subjects with the apolipoprotein E-epsilon4 allele at risk for age-related memory disorders PMID 12774299
- Theranostic pair
- —
Regulatory status
- FDA
- —
- EMA (centralised)
- —
- Other approvals
- —
- Brand names
- —
Clinical use
- Typical injected activity
- —
- Uptake time
- —
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | HPLC | 29±4% no | — | 3-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-ylthio)propyl 4-methylbenzenesulfonate | 19186063 2009 Appl Radiat Isot automated using a GE TRACERlab FX(FN) radiosynthesis module — Formulated [(18)F]FP-TZTP was prepared in an uncorrected radiochemical yield of 29+/-4% |
| — | — | — | 18.8% | — | — | 12493545 2003 Nucl Med Biol A number of hardware and software modifications to a Nuclear Interface C-11 Methylation System provided the equipment for the automated radiosynthesis. — The automated synthesis unit provided the product in a radiochemical yield of 18.8% +/- 2.4% (EOS, n = 25) |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]FP-TZTP.
Get in touchNotes
Added from reverse module search (stage 6); 2 article(s) with F-18. | Stage 28: added indication(s) psy-mood from consolidated missing-rubric review.