Structure of FP-TZTP (unlabelled parent compound, from PubChem) — Unlabelled parent compoundPubChem CID 10107360

[18F]FP-TZTP

Also written as [18F]FP-TZTP; [F-18]FP-TZTP

Radionuclide: F-18 t½ 109.77 min
Modality: PET
Production route: —
Stage: —
Syntheses indexed: 2

Alzheimer's disease CNS receptor and transporter imaging Mood and anxiety disorders (depression, bipolar disorder, anxiety, OCD)

What it is

Compound class: M2 selective muscarinic acetylcholine receptor agonist radioligand
Target / mechanism: Muscarinic acetylcholine receptor subtype 2 (M2) PMID 19186063
Clinical application: Aging subjects with the apolipoprotein E-epsilon4 allele at risk for age-related memory disorders PMID 12774299
Theranostic pair: —

Published syntheses

Module	Cassette	Purification	Yield %	RCP %	Precursor / supplier	Source
TRACERlab FX FN GE HealthCare	—	HPLC	29±4% not corrected	—	3-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-y…3-(4-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)-1,2,5-thiadiazol-3-ylthio)propyl 4-methylbenzenesulfonate	19186063 2009 Appl Radiat Isot automated using a GE TRACERlab FX(FN) radiosynthesis module - Formulated [(18)F]FP-TZTP was prepared in an uncorrected radiochemical yield of 29+/-4%
Nuclear Interface Nuclear Interface (legacy)	—	—	18.8%	—	—	12493545 2003 Nucl Med Biol A number of hardware and software modifications to a Nuclear Interface C-11 Methylation System provided the equipment for the automated radiosynthesis. - The automated synthesis unit provided the product in a radiochemical yield of 18.8% +/- 2.4% (EOS, n = 25)

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Quality control Preliminary - inferred from compound class

Ph. Eur. monograph: not verified No Ph. Eur. check is recorded for this entry.
USP monograph: not verified No USP check is recorded for this entry.

AppearancepHRCP HPLCRCP TLCHPLC UVRadionuclidic (HPGe)Half-lifeActivityEndotoxins (LAL)SterilityFilter integrity

How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)

Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived

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Notes

Added from reverse module search (stage 6); 2 article(s) with F-18. | Stage 28: added indication(s) psy-mood from consolidated missing-rubric review.