Tracers / [18F]flutemetamol
[18F]flutemetamol
Also written as [18F]Flutemetamol; [F-18]Flutemetamol; Flutemetamol
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- Approved
- Syntheses indexed
- 7
What it is
- Compound class
- Radiolabelled benzothiazole derivative (amyloid-binding small molecule)
- Target / mechanism
- β-amyloid aggregates FDA label NDA203137
- Clinical application
- PET imaging of the brain to estimate β-amyloid neuritic plaque density in adults with cognitive impairment, for evaluation of Alzheimer's disease and other causes of cognitive decline FDA label NDA203137
- Theranostic pair
- —
Regulatory status
- FDA
- 2013, Vizamyl, GE Healthcare FDA (Drugs@FDA/openFDA): NDA203137, approved 2013-10-25
- EMA (centralised)
- 2014, Vizamyl, GE Healthcare EMA medicines register export (2026-09-09): EMEA/H/C/002557, 'Authorised'
- Other approvals
- —
- Brand names
- Vizamyl
Clinical use
- Typical injected activity
- 185 MBq (5 mCi) single IV bolus within 40 seconds, up to 10 mL FDA label NDA203137 (human clinical dosing)
- Uptake time
- Signal increases continually 0–30 min post-injection, then stable from 30 min to at least 120 min FDA label NDA203137
Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| — | — | — | — | — | — | 29499171 2018 Alzheimers Dement |
| — | — | — | — | — | — | 29114726 2017 JAMA Neurol |
| — | — | — | — | — | — | 36539779 2022 Biomed Eng Online |
| — | — | — | — | — | — | 25366546 2015 Pharm Res The influence of polysorbate 80 on the radiochemical synthesis of a PET tracer in the FASTlab. |
| — | — | — | — | — | — | 25146124 2014 J Nucl Med |
| — | — | — | — | — | — | 22301718 2012 Neurodegener Dis |
| — | — | — | — | — | — | 42142951 2026 J Nucl Cardiol |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
- —
- USP monograph
- —
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]flutemetamol.
Get in touchNotes
Added from reverse module search (stage 6); 7 article(s) with F-18.