Tracer library / [18F]fluoromannitol
[18F]fluoromannitol
Also written as [18F]Fluoromannitol; [18F]FMtl; [F-18]Fluoromannitol
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- Fluorinated sugar alcohol (radiolabelled mannitol derivative)
- Target / mechanism
- Pathogen-specific mannitol transporter, selectively taken up by Gram-positive and Gram-negative bacteria PMID 40753675
- Clinical application
- PET imaging of bacterial infection, distinguishing infection from sterile inflammation PMID 40753675
- Theranostic pair
- —
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | custom manifold | SPE | 11.0 ± 2.12% not corrected | >97% | 4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifl…4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifluoromethanesulfonyl-1-O-methyl-β-D-glucopyranoside ABX | 41148529 2025 EJNMMI Radiopharm Chem an automated Trasis AllinOne radiosynthesizer configured with two reactors plus three, 6-port research cassettes custom assembled in series with additional tubing, syringes, and vials - produced product with an EOS average non-decay corrected activity yield of 11.0 ± 2.12% (n = 19) |
| AllinOne (AiO) Trasis | custom manifold | SPE | 11.0 ± 2.12% not corrected | >97% | 4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifl…4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifluoromethanesulfonyl-1-O-methyl-β-D-glucopyranoside ABX | 40766237 2025 Res Sq an automated Trasis AllinOne radiosynthesizer - produced product with an EOS average non-decay corrected activity yield of 11.0 ± 2.12% (n = 19) |
| ELIXYS FLEX/CHEM Sofie | vendor cassette | SPE | 35 ± 2 % | >99 % | 4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifl…4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifluoromethanesulfonyl-1-O-methyl-β-D-glucopyranoside ABX | 40753675 2025 Appl Radiat Isot All radiochemical experiments were performed using the ELIXYS FLEX/CHEM automated synthesizer (Sofie Biosciences). - a radiochemical yield of 35 ± 2 % in 134 ± 2 min (n = 6, Table 1, Table 2). |
Precursor
- Common precursor
- —
- Suppliers seen in the literature
- —
- Cited suppliers in indexed syntheses
- ABX
- Typical final purification
- —
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Get in touchQuality control Preliminary - inferred from compound class
- Ph. Eur. monograph
- not verified No Ph. Eur. check is recorded for this entry.
- USP monograph
- not verified No USP check is recorded for this entry.
How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]fluoromannitol.
Get in touchNotes
Added from reverse module search (stage 6); 5 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 40753675: '4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifluoromethanesulfonyl-1-O-methyl-β-D-glucopyranoside'.