Tracers / [18F]fluoromannitol
[18F]fluoromannitol
Also written as [18F]Fluoromannitol; [18F]FMtl; [F-18]Fluoromannitol
- Radionuclide
- F-18 t½ 109.77 min
- Modality
- PET
- Production route
- —
- Stage
- —
- Syntheses indexed
- 3
What it is
- Compound class
- Fluorinated sugar alcohol (radiolabelled mannitol derivative)
- Target / mechanism
- Pathogen-specific mannitol transporter, selectively taken up by Gram-positive and Gram-negative bacteria PMID 40753675
- Clinical application
- PET imaging of bacterial infection, distinguishing infection from sterile inflammation PMID 40753675
- Theranostic pair
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Regulatory status
- FDA
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- EMA (centralised)
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- Other approvals
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- Brand names
- —
Clinical use
- Typical injected activity
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- Uptake time
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Reported in the literature. Not a dosing recommendation.
Published syntheses
| Module | Cassette | Purification | Yield % | RCP % | Precursor / supplier | Source |
|---|---|---|---|---|---|---|
| AllinOne (AiO) Trasis | custom manifold | SPE | 11.0 ± 2.12% no | >97% | 4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifluoromethanesulfonyl-1-O-methyl-β-D-glucopyranoside ABX | 41148529 2025 EJNMMI Radiopharm Chem an automated Trasis AllinOne radiosynthesizer configured with two reactors plus three, 6-port research cassettes custom assembled in series with additional tubing, syringes, and vials — produced product with an EOS average non-decay corrected activity yield of 11.0 ± 2.12% (n = 19) |
| AllinOne (AiO) Trasis | custom manifold | SPE | 11.0 ± 2.12% no | >97% | 4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifluoromethanesulfonyl-1-O-methyl-β-D-glucopyranoside ABX | 40766237 2025 Res Sq an automated Trasis AllinOne radiosynthesizer — produced product with an EOS average non-decay corrected activity yield of 11.0 ± 2.12% (n = 19) |
| ELIXYS FLEX/CHEM Sofie Biosciences | vendor cassette | SPE | 35 ± 2 % | >99 % | 4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifluoromethanesulfonyl-1-O-methyl-β-D-glucopyranoside ABX | 40753675 2025 Appl Radiat Isot All radiochemical experiments were performed using the ELIXYS FLEX/CHEM automated synthesizer (Sofie Biosciences). — a radiochemical yield of 35 ± 2 % in 134 ± 2 min (n = 6, Table 1, Table 2). |
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Get in touchQuality control Preliminary — inferred from compound class
- Ph. Eur. monograph
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- USP monograph
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How this set was arrived at. base set per Ph. Eur. general monograph 0125 (rule); weak UV chromophore (sugar/simple ion/short-chain acid) -> conductometric detection (rule); organic-phase radiosynthesis assumed from isotope/compound class, no synthesis data confirming it -> GC residual solvents (preliminary); conventional nucleophilic 18F-fluorination assumed from isotope/compound class, no synthesis data confirming K222 use -> Kryptofix test (preliminary)
Tests listed by reference only. Monograph texts are copyrighted and are not reproduced here. How these are derived
Setting up quality control?We can help you scope the equipment needed to release [18F]fluoromannitol.
Get in touchNotes
Added from reverse module search (stage 6); 5 article(s) with F-18. Compound class inferred from precursor name (not stated outright) -- PMID 40753675: '4,6-O-Benzylidene-3-O-ethoxymethyl-2-O-trifluoromethanesulfonyl-1-O-methyl-β-D-glucopyranoside'.